@article{bff43dec44134442a0eda0a55f5828cc,
title = "Role of Exosomes in Dermal Wound Healing: A Systematic Review",
abstract = "Cell-based therapy imparts its therapeutic effects through soluble GFs and vesicular bodies such as exosomes. A systematic review with a meta-analysis of preclinical studies was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the modified Stroke Therapy Academic Industry Roundtable guidelines to identify exosomes as an archetype biological therapy for dermal wound healing and to provide guidelines for the concentrations to be used in preclinical studies. A total of 51 rodent studies were included in the systematic review and 9 were included in the meta-analysis section. Three independent reviewers cross-screened eligibility and selected studies for quality assessment from 3,064 published studies on exosomes and wound healing. The mean quality scores for all studies were 5.08 ± 0.752 and 5.11 ± 1.13 for systematic review and meta-analysis, respectively. Exosome effects were reported to have the highest efficacy at 7 days (OR = 1.82, 95% confidence interval = 0.69‒2.95) than at 14 days (OR = 2.29, 95% confidence interval = 0.01‒4.56) after administration. Exosomes were reported to regulate all phases of skin wound healing, mostly by the actions of circulating microRNA. The outcome of this review may be used to guide preclinical and clinical studies on the role of exosomes in wound healing.",
author = "Anesh Prasai and Jay, {Jayson W.} and Daniel Jupiter and Wolf, {Steven E.} and {El Ayadi}, Amina",
note = "Funding Information: This research would not have been possible without the outstanding support and direction of Julie Trumble, Head of Reference and Educational Services of the Moody Medical Library at the University of Texas Medical Branch, Galveston. We would also like to acknowledge Eileen Figueroa and David Chavarria of the Surgery Department for assistance with formatting the paper. We are also grateful to all the authors who responded to our request for information regarding different aspects of the paper. AP, JWJ, AEA are supported by Remembering the 15 Research Endowment. JWJ is also supported by National Institutes of Health under Award Number T32GM008256. AEA is also supported by NG1078 and R01GM136877. Funding Information: This research would not have been possible without the outstanding support and direction of Julie Trumble, Head of Reference and Educational Services of the Moody Medical Library at the University of Texas Medical Branch, Galveston. We would also like to acknowledge Eileen Figueroa and David Chavarria of the Surgery Department for assistance with formatting the paper. We are also grateful to all the authors who responded to our request for information regarding different aspects of the paper. AP, JWJ, AEA are supported by Remembering the 15 Research Endowment. JWJ is also supported by National Institutes of Health under Award Number T32GM008256. AEA is also supported by NG1078 and R01GM136877. Conceptualization: AEA, AP, DJ, JWJ; Data Curation: AEA, AP, DJ, JWJ; Formal Analysis: AEA, AP, DJ, JWJ; Writing ? Original Draft Preparation: AEA, AP, DJ, JWJ, SEW; Writing ? Review and Editing: AEA, AP, DJ, JWJ, SEW, Accountability for all aspects of work related to accuracy and integrity: AE, AP, DJ, JJ, SEW Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2022",
month = mar,
doi = "10.1016/j.jid.2021.07.167",
language = "English (US)",
volume = "142",
pages = "662--678.e8",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "3",
}