Role of fat metabolism in burn trauma-induced skeletal muscle insulin resistance

Melanie G. Cree, Asle Aarsland, David N. Herndon, Robert R. Wolfe

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

OBJECTIVE: Review current evidence on the role of fat in posttrauma insulin resistance, in reference to new studies with peroxisome proliferating activating receptor-α agonists. DESIGN: Review. SETTING: University laboratory. PATIENTS: Thirty pediatric burn trauma patients. INTERVENTIONS: Fourteen days of peroxisome proliferating activating receptor-α agonist immediately following burn trauma. MEASUREMENTS AND MAIN RESULTS: We measured glucose metabolism and fat metabolism via tracer methodology and intracellular measurements. Insulin-stimulated glucose uptake is impaired following burn trauma, as is intracellular insulin signaling, palmitate oxidation, and mitochondrial oxidative capacity. Furthermore, levels of intracellular lipids are increased. Two weeks of peroxisome proliferating activating receptor-α treatment significantly reverses these pathologic changes incurred from burn injury. CONCLUSIONS: Severe burn injury seriously affects multiple aspects of glucose and fat metabolism within the muscle, which can adversely affect clinical outcomes. Treatment with a peroxisome proliferating activating receptor-α drug may be a potential new therapeutic option.

Original languageEnglish (US)
Pages (from-to)S476-S483
JournalCritical care medicine
Volume35
Issue number9 SUPPL.
DOIs
StatePublished - Sep 1 2007

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Keywords

  • Burn trauma
  • Fat oxidation
  • Insulin resistance
  • Intracellular insulin signaling
  • Mitochondrial substrate oxidation
  • Muscle metabolism
  • Pediatrics

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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