Role of flagellin in the pathogenesis of shock and acute respiratory distress syndrome: Therapeutic opportunities

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To provide an overview of the role of flagellin as an immunostimulatory and proinflammatory factor. Design: A systematic overview of the literature on this subject. Setting: An office equipped with a computer and Internet access to PubMed. Subjects: MEDLINE citations between 1960 and 2002. Main Results: Flagellin, a protein of 40-60 kD, is the principal constituent of the flagellum, a prominent surface structure found in motile bacteria. Recent work reveals that monomeric flagellin, a protein component of flagellated bacteria, can act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the toll-like receptor 5-nuclear factor-κB axis. Monocytes, macrophages, and intestinal and pulmonary epithelial cells respond to monomeric flagellin at low concentrations. Monomeric flagellin can induce prominent local and systemic immune/inflammatory responses in vitro and in vivo. Conclusions: Recognition of the flagellin-toll-like receptor 5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, and acute respiratory distress syndrome.

Original languageEnglish (US)
JournalCritical Care Medicine
Volume31
Issue number1 SUPPL.
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Flagellin
Adult Respiratory Distress Syndrome
Shock
Toll-Like Receptor 5
Therapeutics
Bacteria
Investigational Therapies
Flagella
Alveolar Macrophages
Immunologic Factors
PubMed
MEDLINE
Internet
Monocytes
Sepsis
Proteins
Epithelial Cells

Keywords

  • Acute respiratory distress syndrome
  • Adhesion
  • Bacteria
  • Epithelium
  • Flagellin
  • Infection
  • Inflammation
  • Macrophage
  • Nuclear factor-κβ
  • Sepsis
  • Shock

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

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title = "Role of flagellin in the pathogenesis of shock and acute respiratory distress syndrome: Therapeutic opportunities",
abstract = "Objective: To provide an overview of the role of flagellin as an immunostimulatory and proinflammatory factor. Design: A systematic overview of the literature on this subject. Setting: An office equipped with a computer and Internet access to PubMed. Subjects: MEDLINE citations between 1960 and 2002. Main Results: Flagellin, a protein of 40-60 kD, is the principal constituent of the flagellum, a prominent surface structure found in motile bacteria. Recent work reveals that monomeric flagellin, a protein component of flagellated bacteria, can act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the toll-like receptor 5-nuclear factor-κB axis. Monocytes, macrophages, and intestinal and pulmonary epithelial cells respond to monomeric flagellin at low concentrations. Monomeric flagellin can induce prominent local and systemic immune/inflammatory responses in vitro and in vivo. Conclusions: Recognition of the flagellin-toll-like receptor 5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, and acute respiratory distress syndrome.",
keywords = "Acute respiratory distress syndrome, Adhesion, Bacteria, Epithelium, Flagellin, Infection, Inflammation, Macrophage, Nuclear factor-κβ, Sepsis, Shock",
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T1 - Role of flagellin in the pathogenesis of shock and acute respiratory distress syndrome

T2 - Therapeutic opportunities

AU - Szabo, Csaba

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N2 - Objective: To provide an overview of the role of flagellin as an immunostimulatory and proinflammatory factor. Design: A systematic overview of the literature on this subject. Setting: An office equipped with a computer and Internet access to PubMed. Subjects: MEDLINE citations between 1960 and 2002. Main Results: Flagellin, a protein of 40-60 kD, is the principal constituent of the flagellum, a prominent surface structure found in motile bacteria. Recent work reveals that monomeric flagellin, a protein component of flagellated bacteria, can act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the toll-like receptor 5-nuclear factor-κB axis. Monocytes, macrophages, and intestinal and pulmonary epithelial cells respond to monomeric flagellin at low concentrations. Monomeric flagellin can induce prominent local and systemic immune/inflammatory responses in vitro and in vivo. Conclusions: Recognition of the flagellin-toll-like receptor 5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, and acute respiratory distress syndrome.

AB - Objective: To provide an overview of the role of flagellin as an immunostimulatory and proinflammatory factor. Design: A systematic overview of the literature on this subject. Setting: An office equipped with a computer and Internet access to PubMed. Subjects: MEDLINE citations between 1960 and 2002. Main Results: Flagellin, a protein of 40-60 kD, is the principal constituent of the flagellum, a prominent surface structure found in motile bacteria. Recent work reveals that monomeric flagellin, a protein component of flagellated bacteria, can act as a soluble immunostimulatory and proinflammatory factor, activating the immune/inflammatory axis via the toll-like receptor 5-nuclear factor-κB axis. Monocytes, macrophages, and intestinal and pulmonary epithelial cells respond to monomeric flagellin at low concentrations. Monomeric flagellin can induce prominent local and systemic immune/inflammatory responses in vitro and in vivo. Conclusions: Recognition of the flagellin-toll-like receptor 5 pathway offers novel opportunities for the experimental therapy of various forms of shock, sepsis, and acute respiratory distress syndrome.

KW - Acute respiratory distress syndrome

KW - Adhesion

KW - Bacteria

KW - Epithelium

KW - Flagellin

KW - Infection

KW - Inflammation

KW - Macrophage

KW - Nuclear factor-κβ

KW - Sepsis

KW - Shock

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