Abstract
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid malignancy. This study retrospectively reviewed 10 fine-needle aspiration samples from six MTC patients. Aspirated specimens were from thyroid (3), cervical lymph nodes (5), left lung (1), and anterior chest wall (1). Cytomorphology consisted predominantly of plasmacytoid cells (3 cases), spindle cells (2 cases), and epithelioid cells (1 case). However, all specimens had a mixture of other cell types and "salt and pepper" chromatin. Only one specimen showed Congo-red-positive amyloid. Calcitonin was expressed in 7/7 specimens. Four patients underwent surgical excision and MTC was confirmed in all four. Follow-up studies included serum calcitonin (3/6 cases) and imaging (2/6 cases). One patient had MTC associated with multiple endocrine neoplasia IIA syndrome and one had familial MTC with a history of MTC in mother. In conclusion, the cytomorphology of MTC is typical and calcitonin immunostain is a reliable method for confirming primary or metastatic MTC. Early cytological diagnosis of MTC positively impacted patient management. Follow-up with serum calcitonin and imaging is helpful in the early detection of recurrences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 285-292 |
| Number of pages | 8 |
| Journal | Diagnostic Cytopathology |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2007 |
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Keywords
- Diagnosis
- FNA cytology
- Immunochemistry
- Management
- Medullary carcinoma
- Thyroid
ASJC Scopus subject areas
- Anatomy
Cite this
Role of FNA cytology and immunochemistry in the diagnosis and management of medullary thyroid carcinoma : Report of six cases and review of the literature. / Bhanot, Punam; Yang, Jack; Schnadig, Vicki J.; Logroño, Roberto.
In: Diagnostic Cytopathology, Vol. 35, No. 5, 05.2007, p. 285-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of FNA cytology and immunochemistry in the diagnosis and management of medullary thyroid carcinoma
T2 - Report of six cases and review of the literature
AU - Bhanot, Punam
AU - Yang, Jack
AU - Schnadig, Vicki J.
AU - Logroño, Roberto
PY - 2007/5
Y1 - 2007/5
N2 - Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid malignancy. This study retrospectively reviewed 10 fine-needle aspiration samples from six MTC patients. Aspirated specimens were from thyroid (3), cervical lymph nodes (5), left lung (1), and anterior chest wall (1). Cytomorphology consisted predominantly of plasmacytoid cells (3 cases), spindle cells (2 cases), and epithelioid cells (1 case). However, all specimens had a mixture of other cell types and "salt and pepper" chromatin. Only one specimen showed Congo-red-positive amyloid. Calcitonin was expressed in 7/7 specimens. Four patients underwent surgical excision and MTC was confirmed in all four. Follow-up studies included serum calcitonin (3/6 cases) and imaging (2/6 cases). One patient had MTC associated with multiple endocrine neoplasia IIA syndrome and one had familial MTC with a history of MTC in mother. In conclusion, the cytomorphology of MTC is typical and calcitonin immunostain is a reliable method for confirming primary or metastatic MTC. Early cytological diagnosis of MTC positively impacted patient management. Follow-up with serum calcitonin and imaging is helpful in the early detection of recurrences.
AB - Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid malignancy. This study retrospectively reviewed 10 fine-needle aspiration samples from six MTC patients. Aspirated specimens were from thyroid (3), cervical lymph nodes (5), left lung (1), and anterior chest wall (1). Cytomorphology consisted predominantly of plasmacytoid cells (3 cases), spindle cells (2 cases), and epithelioid cells (1 case). However, all specimens had a mixture of other cell types and "salt and pepper" chromatin. Only one specimen showed Congo-red-positive amyloid. Calcitonin was expressed in 7/7 specimens. Four patients underwent surgical excision and MTC was confirmed in all four. Follow-up studies included serum calcitonin (3/6 cases) and imaging (2/6 cases). One patient had MTC associated with multiple endocrine neoplasia IIA syndrome and one had familial MTC with a history of MTC in mother. In conclusion, the cytomorphology of MTC is typical and calcitonin immunostain is a reliable method for confirming primary or metastatic MTC. Early cytological diagnosis of MTC positively impacted patient management. Follow-up with serum calcitonin and imaging is helpful in the early detection of recurrences.
KW - Diagnosis
KW - FNA cytology
KW - Immunochemistry
KW - Management
KW - Medullary carcinoma
KW - Thyroid
UR - http://www.scopus.com/inward/record.url?scp=34247520136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247520136&partnerID=8YFLogxK
U2 - 10.1002/dc.20502
DO - 10.1002/dc.20502
M3 - Article
C2 - 17427218
AN - SCOPUS:34247520136
VL - 35
SP - 285
EP - 292
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
SN - 8755-1039
IS - 5
ER -