Role of glycosylation in protein disulfide formation and cataractogenesis

Naseem Ansari, Y. C. Awasthi, Satish Srivastava

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Abstract

In order to study if glycosylation plays a role in the formation of protein disulfides and cataractogenesis, the levels of total sulfhydryl, GSH, protein disulfides (PSSP), protein mixed disulfide (PSSG) and the extent of glycosylation has been determined in normal, senile cataractous and diabetic cataractous lenses. No correlation between the extent of glycosylation and the total disulfide, PSSP or PSSG was observed in the normal, senile cataractous or diabetic cataractous lenses. This indicated that glycosylation probably does not play a primary role in cataract formation in diabetic patients.

Original languageEnglish
Pages (from-to)9-19
Number of pages11
JournalExperimental Eye Research
Volume31
Issue number1
StatePublished - 1980

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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