Role of glycosylation in protein disulfide formation and cataractogenesis

Naseem H. Ansari; Yogesh C. Awasthi; Satish K. Srivastava

doi:10.1016/0014-4835(80)90086-X

Role of glycosylation in protein disulfide formation and cataractogenesis

Naseem H. Ansari, Yogesh C. Awasthi, Satish K. Srivastava

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59 Scopus citations

Abstract

In order to study if glycosylation plays a role in the formation of protein disulfides and cataractogenesis, the levels of total sulfhydryl, GSH, protein disulfides (PSSP), protein mixed disulfide (PSSG) and the extent of glycosylation has been determined in normal, senile cataractous and diabetic cataractous lenses. No correlation between the extent of glycosylation and the total disulfide, PSSP or PSSG was observed in the normal, senile cataractous or diabetic cataractous lenses. This indicated that glycosylation probably does not play a primary role in cataract formation in diabetic patients.

Original language	English (US)
Pages (from-to)	9-19
Number of pages	11
Journal	Experimental Eye Research
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/0014-4835(80)90086-X
State	Published - 1980
Externally published	Yes

Keywords

cataractogenesis
diabetic cataract
disulfide
glycosylation
senile cataract
sulfhydryl

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(80)90086-X

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abstract = "In order to study if glycosylation plays a role in the formation of protein disulfides and cataractogenesis, the levels of total sulfhydryl, GSH, protein disulfides (PSSP), protein mixed disulfide (PSSG) and the extent of glycosylation has been determined in normal, senile cataractous and diabetic cataractous lenses. No correlation between the extent of glycosylation and the total disulfide, PSSP or PSSG was observed in the normal, senile cataractous or diabetic cataractous lenses. This indicated that glycosylation probably does not play a primary role in cataract formation in diabetic patients.",

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T1 - Role of glycosylation in protein disulfide formation and cataractogenesis

AU - Ansari, Naseem H.

AU - Awasthi, Yogesh C.

AU - Srivastava, Satish K.

PY - 1980

Y1 - 1980

N2 - In order to study if glycosylation plays a role in the formation of protein disulfides and cataractogenesis, the levels of total sulfhydryl, GSH, protein disulfides (PSSP), protein mixed disulfide (PSSG) and the extent of glycosylation has been determined in normal, senile cataractous and diabetic cataractous lenses. No correlation between the extent of glycosylation and the total disulfide, PSSP or PSSG was observed in the normal, senile cataractous or diabetic cataractous lenses. This indicated that glycosylation probably does not play a primary role in cataract formation in diabetic patients.

AB - In order to study if glycosylation plays a role in the formation of protein disulfides and cataractogenesis, the levels of total sulfhydryl, GSH, protein disulfides (PSSP), protein mixed disulfide (PSSG) and the extent of glycosylation has been determined in normal, senile cataractous and diabetic cataractous lenses. No correlation between the extent of glycosylation and the total disulfide, PSSP or PSSG was observed in the normal, senile cataractous or diabetic cataractous lenses. This indicated that glycosylation probably does not play a primary role in cataract formation in diabetic patients.

KW - cataractogenesis

KW - diabetic cataract

KW - disulfide

KW - glycosylation

KW - senile cataract

KW - sulfhydryl

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Role of glycosylation in protein disulfide formation and cataractogenesis

Abstract

Keywords

ASJC Scopus subject areas

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