Role of glycosylation in protein disulfide formation and cataractogenesis

Naseem H. Ansari, Yogesh C. Awasthi, Satish K. Srivastava

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

In order to study if glycosylation plays a role in the formation of protein disulfides and cataractogenesis, the levels of total sulfhydryl, GSH, protein disulfides (PSSP), protein mixed disulfide (PSSG) and the extent of glycosylation has been determined in normal, senile cataractous and diabetic cataractous lenses. No correlation between the extent of glycosylation and the total disulfide, PSSP or PSSG was observed in the normal, senile cataractous or diabetic cataractous lenses. This indicated that glycosylation probably does not play a primary role in cataract formation in diabetic patients.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalExperimental Eye Research
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1980

Keywords

  • cataractogenesis
  • diabetic cataract
  • disulfide
  • glycosylation
  • senile cataract
  • sulfhydryl

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Role of glycosylation in protein disulfide formation and cataractogenesis'. Together they form a unique fingerprint.

  • Cite this