Role of IL-5 during primary and secondary immune response to acetylcholine receptor

Mathilde A. Poussin, Elzbieta Goluszko, Juan U. Franco, Premkumar Christadoss

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalJournal of Neuroimmunology
Volume125
Issue number1-2
DOIs
StatePublished - 2002

Fingerprint

Autoimmune Experimental Myasthenia Gravis
Interleukin-5
Cholinergic Receptors
Knockout Mice
Gene Knockout Techniques
Inbred C57BL Mouse
Antibody Formation
Immunization
Lymphocytes
Cytokines
Muscles
Incidence

Keywords

  • Autoimmunity
  • IL-5
  • IL-5 gene knockout
  • Immunomodulation
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Role of IL-5 during primary and secondary immune response to acetylcholine receptor. / Poussin, Mathilde A.; Goluszko, Elzbieta; Franco, Juan U.; Christadoss, Premkumar.

In: Journal of Neuroimmunology, Vol. 125, No. 1-2, 2002, p. 51-58.

Research output: Contribution to journalArticle

Poussin, Mathilde A. ; Goluszko, Elzbieta ; Franco, Juan U. ; Christadoss, Premkumar. / Role of IL-5 during primary and secondary immune response to acetylcholine receptor. In: Journal of Neuroimmunology. 2002 ; Vol. 125, No. 1-2. pp. 51-58.
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