Role of IL-5 during primary and secondary immune response to acetylcholine receptor

Mathilde A. Poussin, Elzbieta Goluszko, Juan U. Franco, Premkumar Christadoss

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalJournal of Neuroimmunology
Volume125
Issue number1-2
DOIs
StatePublished - Apr 27 2002

Keywords

  • Autoimmunity
  • IL-5
  • IL-5 gene knockout
  • Immunomodulation
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Role of IL-5 during primary and secondary immune response to acetylcholine receptor'. Together they form a unique fingerprint.

  • Cite this