Role of IL-5 during primary and secondary immune response to acetylcholine receptor

Mathilde A. Poussin; Elzbieta Goluszko; Juan U. Franco; Premkumar Christadoss

doi:10.1016/S0165-5728(02)00030-9

Role of IL-5 during primary and secondary immune response to acetylcholine receptor

Mathilde A. Poussin, Elzbieta Goluszko, Juan U. Franco, Premkumar Christadoss

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.

Original language	English (US)
Pages (from-to)	51-58
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	125
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(02)00030-9
State	Published - 2002
Externally published	Yes

Keywords

Autoimmunity
IL-5
IL-5 gene knockout
Immunomodulation
Myasthenia gravis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(02)00030-9

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@article{f2f8c1ef11af4607b33b403a5b12d42c,

title = "Role of IL-5 during primary and secondary immune response to acetylcholine receptor",

abstract = "To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.",

keywords = "Autoimmunity, IL-5, IL-5 gene knockout, Immunomodulation, Myasthenia gravis",

author = "Poussin, \{Mathilde A.\} and Elzbieta Goluszko and Franco, \{Juan U.\} and Premkumar Christadoss",

note = "Funding Information: This work was supported by grants from the Association Fran{\c c}aise contre les Myopathies and Myasthenia Gravis Foundation of America. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2002",

doi = "10.1016/S0165-5728(02)00030-9",

language = "English (US)",

volume = "125",

pages = "51--58",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Role of IL-5 during primary and secondary immune response to acetylcholine receptor

AU - Poussin, Mathilde A.

AU - Goluszko, Elzbieta

AU - Franco, Juan U.

AU - Christadoss, Premkumar

N1 - Funding Information: This work was supported by grants from the Association Française contre les Myopathies and Myasthenia Gravis Foundation of America. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2002

Y1 - 2002

N2 - To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.

AB - To analyze the role of the Th2 cytokine interleukin-5 (IL-5) in experimental autoimmune myasthenia gravis (EAMG) pathogenesis, we induced clinical EAMG in C57BL/6 and IL-5 gene-knockout (KO) mice in the C57BL/6 background. IL-5 KO mice had a significantly reduced incidence and severity of EAMG. Despite their increased resistance to EAMG, IL-5 KO mice displayed intact secondary antibody and lymphoproliferative responses to acetylcholine receptor (AChR) after immunization with this molecule. However, the relative resistance of IL-5 KO mice was associated with a reduced primary lymphocyte response to AChR, and reduced C3 levels in muscle extracts compared to those in C57BL/6 mice.

KW - Autoimmunity

KW - IL-5

KW - IL-5 gene knockout

KW - Immunomodulation

KW - Myasthenia gravis

UR - https://www.scopus.com/pages/publications/0036224110

UR - https://www.scopus.com/inward/citedby.url?scp=0036224110&partnerID=8YFLogxK

U2 - 10.1016/S0165-5728(02)00030-9

DO - 10.1016/S0165-5728(02)00030-9

M3 - Article

C2 - 11960640

AN - SCOPUS:0036224110

SN - 0165-5728

VL - 125

SP - 51

EP - 58

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Role of IL-5 during primary and secondary immune response to acetylcholine receptor

Abstract

Keywords

ASJC Scopus subject areas

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