Role of interferon in leukocyte histamine release caused by common respiratory viruses

T. Chonmaitree, M. A. Lett-Brown, Y. Tsong, A. S. Goldman, S. Baron

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Asthmatic attacks are often precipitated by viral respiratory infections. The mechanism of virus-induced asthma is still unclear. Interferon could be an important mediator in virus-induced hypersensitivity reactions, because interferon is induced by some respiratory viruses, and it can enhance IgE-mediated histamine release in vitro. We studied the effect of common respiratory viruses, including both interferon inducers and non-interferon inducers, on IgE-mediated leukocyte histamine release. Leukocytes from healthy, nonallergic donors were exposed to different strains of respiratory viruses, and basophils were challenged with antibody to IgE to release histamine. We found that the viruses are capable of enhancing IgE-mediated histamine release in the presence or absence of interferon. Our results suggest that although interferon may play a role in virus-induced hypersensitivity reactions, other mechanisms probably also play a significant role.

Original languageEnglish (US)
Pages (from-to)127-132
Number of pages6
JournalJournal of Infectious Diseases
Volume157
Issue number1
StatePublished - 1988

Fingerprint

Histamine Release
Interferon-alpha
Viruses
Interferons
Immunoglobulin E
Hypersensitivity
Leukocytes
Interferon Inducers
Basophils
Virus Diseases
Respiratory Tract Infections
Asthma
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Chonmaitree, T., Lett-Brown, M. A., Tsong, Y., Goldman, A. S., & Baron, S. (1988). Role of interferon in leukocyte histamine release caused by common respiratory viruses. Journal of Infectious Diseases, 157(1), 127-132.

Role of interferon in leukocyte histamine release caused by common respiratory viruses. / Chonmaitree, T.; Lett-Brown, M. A.; Tsong, Y.; Goldman, A. S.; Baron, S.

In: Journal of Infectious Diseases, Vol. 157, No. 1, 1988, p. 127-132.

Research output: Contribution to journalArticle

Chonmaitree, T, Lett-Brown, MA, Tsong, Y, Goldman, AS & Baron, S 1988, 'Role of interferon in leukocyte histamine release caused by common respiratory viruses', Journal of Infectious Diseases, vol. 157, no. 1, pp. 127-132.
Chonmaitree T, Lett-Brown MA, Tsong Y, Goldman AS, Baron S. Role of interferon in leukocyte histamine release caused by common respiratory viruses. Journal of Infectious Diseases. 1988;157(1):127-132.
Chonmaitree, T. ; Lett-Brown, M. A. ; Tsong, Y. ; Goldman, A. S. ; Baron, S. / Role of interferon in leukocyte histamine release caused by common respiratory viruses. In: Journal of Infectious Diseases. 1988 ; Vol. 157, No. 1. pp. 127-132.
@article{9fa104f526b44ee2be22a1d34b3b4089,
title = "Role of interferon in leukocyte histamine release caused by common respiratory viruses",
abstract = "Asthmatic attacks are often precipitated by viral respiratory infections. The mechanism of virus-induced asthma is still unclear. Interferon could be an important mediator in virus-induced hypersensitivity reactions, because interferon is induced by some respiratory viruses, and it can enhance IgE-mediated histamine release in vitro. We studied the effect of common respiratory viruses, including both interferon inducers and non-interferon inducers, on IgE-mediated leukocyte histamine release. Leukocytes from healthy, nonallergic donors were exposed to different strains of respiratory viruses, and basophils were challenged with antibody to IgE to release histamine. We found that the viruses are capable of enhancing IgE-mediated histamine release in the presence or absence of interferon. Our results suggest that although interferon may play a role in virus-induced hypersensitivity reactions, other mechanisms probably also play a significant role.",
author = "T. Chonmaitree and Lett-Brown, {M. A.} and Y. Tsong and Goldman, {A. S.} and S. Baron",
year = "1988",
language = "English (US)",
volume = "157",
pages = "127--132",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Role of interferon in leukocyte histamine release caused by common respiratory viruses

AU - Chonmaitree, T.

AU - Lett-Brown, M. A.

AU - Tsong, Y.

AU - Goldman, A. S.

AU - Baron, S.

PY - 1988

Y1 - 1988

N2 - Asthmatic attacks are often precipitated by viral respiratory infections. The mechanism of virus-induced asthma is still unclear. Interferon could be an important mediator in virus-induced hypersensitivity reactions, because interferon is induced by some respiratory viruses, and it can enhance IgE-mediated histamine release in vitro. We studied the effect of common respiratory viruses, including both interferon inducers and non-interferon inducers, on IgE-mediated leukocyte histamine release. Leukocytes from healthy, nonallergic donors were exposed to different strains of respiratory viruses, and basophils were challenged with antibody to IgE to release histamine. We found that the viruses are capable of enhancing IgE-mediated histamine release in the presence or absence of interferon. Our results suggest that although interferon may play a role in virus-induced hypersensitivity reactions, other mechanisms probably also play a significant role.

AB - Asthmatic attacks are often precipitated by viral respiratory infections. The mechanism of virus-induced asthma is still unclear. Interferon could be an important mediator in virus-induced hypersensitivity reactions, because interferon is induced by some respiratory viruses, and it can enhance IgE-mediated histamine release in vitro. We studied the effect of common respiratory viruses, including both interferon inducers and non-interferon inducers, on IgE-mediated leukocyte histamine release. Leukocytes from healthy, nonallergic donors were exposed to different strains of respiratory viruses, and basophils were challenged with antibody to IgE to release histamine. We found that the viruses are capable of enhancing IgE-mediated histamine release in the presence or absence of interferon. Our results suggest that although interferon may play a role in virus-induced hypersensitivity reactions, other mechanisms probably also play a significant role.

UR - http://www.scopus.com/inward/record.url?scp=0023852252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023852252&partnerID=8YFLogxK

M3 - Article

C2 - 2447197

AN - SCOPUS:0023852252

VL - 157

SP - 127

EP - 132

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -