Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep

Hiroyuki Sakurai, Frank C. Schmalstieg, Lillian D. Traber, Hal K. Hawkins, Daniel L. Traber

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The effects of a monoclonal antibody against L-selectin [leukoctye adhesion molecule (LAM)1-3] on microvascular fluid flux were determined in conscious sheep subjected to a combined injury of 40% third-degree burn and smoke inhalation. This combined injury induced a rapid increase in systemic prefemoral lymph flow (sQ̇(lymph)) from the burned area and a delayed-onset increase in lung lymph flow. The initial increase in sQ̇(lymph) was associated with an elevation of the lymph-to-plasma oncotic pressure ratio; consequently, it leads to a predominant increase in the systemic soft tissue permeability index (sPI). In an untreated control group, the increased sPI was sustained beyond 24 h after injury. Pretreatment with LAM1-3 resulted in earlier recovery from. The increased sPI, although the initial responses in sQ(lymph) and sPI were identical to those in the nontreatment group. The delayed-onset lung permeability changes were significantly attenuated by pretreatment with LAM1-3. These findings indicate that both leukocyte- dependent and -independent mechanisms are involved in the pathogenesis that occurs after combined injury with burn and smoke inhalation.

Original languageEnglish (US)
Pages (from-to)1151-1159
Number of pages9
JournalJournal of Applied Physiology
Volume86
Issue number4
StatePublished - Apr 1999

Fingerprint

Smoke Inhalation Injury
L-Selectin
Lymph
Sheep
Permeability
Inhalation Burns
Wounds and Injuries
Smoke
Lung
Leukocytes
Monoclonal Antibodies
Pressure
Control Groups

Keywords

  • Fluid balance
  • Hemodynamics
  • Lung lymph
  • Sheep
  • Systemic prefemoral lymph

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Sakurai, H., Schmalstieg, F. C., Traber, L. D., Hawkins, H. K., & Traber, D. L. (1999). Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. Journal of Applied Physiology, 86(4), 1151-1159.

Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. / Sakurai, Hiroyuki; Schmalstieg, Frank C.; Traber, Lillian D.; Hawkins, Hal K.; Traber, Daniel L.

In: Journal of Applied Physiology, Vol. 86, No. 4, 04.1999, p. 1151-1159.

Research output: Contribution to journalArticle

Sakurai, H, Schmalstieg, FC, Traber, LD, Hawkins, HK & Traber, DL 1999, 'Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep', Journal of Applied Physiology, vol. 86, no. 4, pp. 1151-1159.
Sakurai H, Schmalstieg FC, Traber LD, Hawkins HK, Traber DL. Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. Journal of Applied Physiology. 1999 Apr;86(4):1151-1159.
Sakurai, Hiroyuki ; Schmalstieg, Frank C. ; Traber, Lillian D. ; Hawkins, Hal K. ; Traber, Daniel L. / Role of L-selectin in physiological manifestations after burn and smoke inhalation injury in sheep. In: Journal of Applied Physiology. 1999 ; Vol. 86, No. 4. pp. 1151-1159.
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