Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media

Janak Patel, Tommy Sim, Tasnee Chonmaitree, Roberto Garofalo, Mary J. Owen, Tatsuo Uchida, Virgil M. Howie

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

In order to evaluate the role of polymorphonuclear leukocytes (PMNs) in acute otitis media (AOM), levels of lankotriene B4 (LTB4), a potent inflammatory product of PMNs, and interleukin-8 (IL-8), a PMN chemotactic cytokine, were measured in 271 middle ear fluid (MEF) samples from 106 children with AOM. Forty-two percent of the patients had evidence of respiratory viral infection. At the time of diagnosis, levels of both LTE4 and IL-8 were higher in the MEFs from patients with AOM associated with bacterial or bacterial and vital infection than those MEFs containing no pathogen (p < .05). Antibiotic treatment was not associated with a significant change in levels of LTB4 or IL-8 in the MEFs obtained 2 to 5 days into treatment, compared to those obtained at diagnosis. Bacteriologic failure after 2 to 5 days of treatment was associated with high LTB4 levels in the initial MEFs (p = .05). Recurrence of AOM within 1 month was associated with high IL-8 levels in the initial MEF (p = .04). Our findings suggest that LTB4 and IL-8 are produced during acute infection of the middle ear, and these PMN-related inflammatory substances may play an important role in delaying recovery or in recurrence of AOM. Effective treatment of AOM may require eradication of bacteria by antibiotics, as well as pharmacologic agents that modulate PMN functions.

Original languageEnglish (US)
Pages (from-to)968-974
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume105
Issue number12
StatePublished - Dec 1996

Fingerprint

Leukotriene B4
Otitis Media
Interleukin-8
Middle Ear
Leukotriene E4
Anti-Bacterial Agents
Recurrence
Virus Diseases
Therapeutics
Chemokines
Bacterial Infections
Respiratory Tract Infections
Neutrophils
Bacteria
Infection

Keywords

  • cytokine
  • interleukin-8
  • leukotriene
  • otitis media
  • respiratory disorder
  • viral disease

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Patel, J., Sim, T., Chonmaitree, T., Garofalo, R., Owen, M. J., Uchida, T., & Howie, V. M. (1996). Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media. Annals of Otology, Rhinology and Laryngology, 105(12), 968-974.

Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media. / Patel, Janak; Sim, Tommy; Chonmaitree, Tasnee; Garofalo, Roberto; Owen, Mary J.; Uchida, Tatsuo; Howie, Virgil M.

In: Annals of Otology, Rhinology and Laryngology, Vol. 105, No. 12, 12.1996, p. 968-974.

Research output: Contribution to journalArticle

Patel, J, Sim, T, Chonmaitree, T, Garofalo, R, Owen, MJ, Uchida, T & Howie, VM 1996, 'Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media', Annals of Otology, Rhinology and Laryngology, vol. 105, no. 12, pp. 968-974.
Patel, Janak ; Sim, Tommy ; Chonmaitree, Tasnee ; Garofalo, Roberto ; Owen, Mary J. ; Uchida, Tatsuo ; Howie, Virgil M. / Role of leukotriene B4 and interleukin-8 in acute bacterial and viral otitis media. In: Annals of Otology, Rhinology and Laryngology. 1996 ; Vol. 105, No. 12. pp. 968-974.
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