Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida

Diana A. Racusin, Sarah Villarreal, Kathleen M. Antony, R. Alan Harris, Joan Mastrobattista, Wesley Lee, Alireza A. Shamshirsaz, Michael Belfort, Kjersti M. Aagaard

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective Midtrimester maternal serum alpha-fetoprotein (MSAFP) and sonographic evaluation have been used to screen for spina bifida. With the increased uptake of cell-free DNA (cfDNA) and first trimester screening, MSAFP levels may no longer be obtained routinely. Our aim was to evaluate a pediatric neurosurgical referral center database of spina bifida cases to determine the antenatal detection rate and means of diagnosis. Study Design Nested case series of all spina bifida cases referred postnatally from 2007 to 2013. Data were abstracted from the maternal record and rates of antenatal detection with MSAFP and sonographic screening were determined. Results Of the 105 postnatally referred cases, 11.4% (12/105) were not identified until delivery. Overall, 39% of the cases had MSAFP screening. The odds ratio for sonogram-based detection of spina bifida was 4.9 (95% confidence interval, 2-11.9). Of the neonatally detected cases, 100% had prenatal care and 91.6% (11 of the 12 cases) had documented sonography. Conclusion We have found that 11.4% of the spina bifida cases were not detected before delivery. Nine out of the 12 cases of antenatally missed spina bifida were not screened using MSAFP. Our findings support the approach of midtrimester MSAFP screening combined with sonographic evaluation. We speculate that prenatal screening with MSAFP is underutilized.

Original languageEnglish (US)
Pages (from-to)1287-1291
Number of pages5
JournalAmerican Journal of Perinatology
Volume32
Issue number14
DOIs
StatePublished - Sep 2 2015
Externally publishedYes

Fingerprint

Spinal Dysraphism
alpha-Fetoproteins
Ultrasonography
Mothers
Serum
Second Pregnancy Trimester
Prenatal Care
First Pregnancy Trimester
Prenatal Diagnosis
Referral and Consultation
Odds Ratio
Databases
Confidence Intervals
Pediatrics
DNA

Keywords

  • MSAFP
  • open neural tube defect
  • prenatal screening
  • spina bifida
  • ultrasound

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida. / Racusin, Diana A.; Villarreal, Sarah; Antony, Kathleen M.; Harris, R. Alan; Mastrobattista, Joan; Lee, Wesley; Shamshirsaz, Alireza A.; Belfort, Michael; Aagaard, Kjersti M.

In: American Journal of Perinatology, Vol. 32, No. 14, 02.09.2015, p. 1287-1291.

Research output: Contribution to journalArticle

Racusin, DA, Villarreal, S, Antony, KM, Harris, RA, Mastrobattista, J, Lee, W, Shamshirsaz, AA, Belfort, M & Aagaard, KM 2015, 'Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida', American Journal of Perinatology, vol. 32, no. 14, pp. 1287-1291. https://doi.org/10.1055/s-0035-1562930
Racusin, Diana A. ; Villarreal, Sarah ; Antony, Kathleen M. ; Harris, R. Alan ; Mastrobattista, Joan ; Lee, Wesley ; Shamshirsaz, Alireza A. ; Belfort, Michael ; Aagaard, Kjersti M. / Role of Maternal Serum Alpha-Fetoprotein and Ultrasonography in Contemporary Detection of Spina Bifida. In: American Journal of Perinatology. 2015 ; Vol. 32, No. 14. pp. 1287-1291.
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AU - Harris, R. Alan

AU - Mastrobattista, Joan

AU - Lee, Wesley

AU - Shamshirsaz, Alireza A.

AU - Belfort, Michael

AU - Aagaard, Kjersti M.

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N2 - Objective Midtrimester maternal serum alpha-fetoprotein (MSAFP) and sonographic evaluation have been used to screen for spina bifida. With the increased uptake of cell-free DNA (cfDNA) and first trimester screening, MSAFP levels may no longer be obtained routinely. Our aim was to evaluate a pediatric neurosurgical referral center database of spina bifida cases to determine the antenatal detection rate and means of diagnosis. Study Design Nested case series of all spina bifida cases referred postnatally from 2007 to 2013. Data were abstracted from the maternal record and rates of antenatal detection with MSAFP and sonographic screening were determined. Results Of the 105 postnatally referred cases, 11.4% (12/105) were not identified until delivery. Overall, 39% of the cases had MSAFP screening. The odds ratio for sonogram-based detection of spina bifida was 4.9 (95% confidence interval, 2-11.9). Of the neonatally detected cases, 100% had prenatal care and 91.6% (11 of the 12 cases) had documented sonography. Conclusion We have found that 11.4% of the spina bifida cases were not detected before delivery. Nine out of the 12 cases of antenatally missed spina bifida were not screened using MSAFP. Our findings support the approach of midtrimester MSAFP screening combined with sonographic evaluation. We speculate that prenatal screening with MSAFP is underutilized.

AB - Objective Midtrimester maternal serum alpha-fetoprotein (MSAFP) and sonographic evaluation have been used to screen for spina bifida. With the increased uptake of cell-free DNA (cfDNA) and first trimester screening, MSAFP levels may no longer be obtained routinely. Our aim was to evaluate a pediatric neurosurgical referral center database of spina bifida cases to determine the antenatal detection rate and means of diagnosis. Study Design Nested case series of all spina bifida cases referred postnatally from 2007 to 2013. Data were abstracted from the maternal record and rates of antenatal detection with MSAFP and sonographic screening were determined. Results Of the 105 postnatally referred cases, 11.4% (12/105) were not identified until delivery. Overall, 39% of the cases had MSAFP screening. The odds ratio for sonogram-based detection of spina bifida was 4.9 (95% confidence interval, 2-11.9). Of the neonatally detected cases, 100% had prenatal care and 91.6% (11 of the 12 cases) had documented sonography. Conclusion We have found that 11.4% of the spina bifida cases were not detected before delivery. Nine out of the 12 cases of antenatally missed spina bifida were not screened using MSAFP. Our findings support the approach of midtrimester MSAFP screening combined with sonographic evaluation. We speculate that prenatal screening with MSAFP is underutilized.

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