Role of microglia in the dissemination of zika virus from mother to fetal brain

Pei Xu, Chao Shan, Tiffany J. Dunn, Xuping Xie, Hongjie Xia, Junling Gao, Javier Allende Labastida, Jing Zou, Paula P. Villarreal, Caitlin R. Schlagal, Yongjia Yu, Gracie Vargas, Shannan L. Rossi, Nikolaos Vasilakis, Pei Yong Shi, Scott C. Weaver, Ping Wu

Research output: Contribution to journalArticle

Abstract

Global Zika virus (ZIKV) outbreaks and their link to microcephaly have raised major public health concerns. However, the mechanism of maternal-fetal transmission remains largely unknown. In this study, we determined the role of yolk sac (YS) microglial progenitors in a mouse model of ZIKV vertical transmission. We found that embryonic (E) days 6.5-E8.5 were a critical window for ZIKV infection that resulted in fetal demise and microcephaly, and YS microglial progenitors were susceptible to ZIKV infection. Ablation of YS microglial progenitors significantly reduced the viral load in both the YS and the embryonic brain. Taken together, these results support the hypothesis that YS microglial progenitors serve as “Trojan horses,” contributing to ZIKV fetal brain dissemination and congenital brain defects.

Original languageEnglish (US)
Article numbere0008413
Pages (from-to)1-21
Number of pages21
JournalPLoS neglected tropical diseases
Volume14
Issue number7
DOIs
StatePublished - Jul 2020

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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