TY - JOUR
T1 - Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal
AU - Althouse, Benjamin M.
AU - Guerbois, Mathilde
AU - Cummings, Derek A.T.
AU - Diop, Ousmane M.
AU - Faye, Ousmane
AU - Faye, Abdourahmane
AU - Diallo, Diawo
AU - Sadio, Bakary Djilocalisse
AU - Sow, Abdourahmane
AU - Faye, Oumar
AU - Sall, Amadou A.
AU - Diallo, Mawlouth
AU - Benefit, Brenda
AU - Simons, Evan
AU - Watts, Douglas M.
AU - Weaver, Scott C.
AU - Hanley, Kathryn A.
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kédougou, Senegal. Over 3 years, 737 monkeys were captured, aged using anthropometry and dentition, and tested for exposure to CHIKV by detection of neutralizing antibodies. Infant monkeys were positive for CHIKV even when the virus was not detected in a concurrent survey of mosquitoes and when population immunity was too high for monkeys alone to support continuous transmission. We conclude that monkeys in this region serve as amplification hosts of CHIKV. Additional efforts are needed to identify other hosts capable of supporting continuous circulation.
AB - Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kédougou, Senegal. Over 3 years, 737 monkeys were captured, aged using anthropometry and dentition, and tested for exposure to CHIKV by detection of neutralizing antibodies. Infant monkeys were positive for CHIKV even when the virus was not detected in a concurrent survey of mosquitoes and when population immunity was too high for monkeys alone to support continuous transmission. We conclude that monkeys in this region serve as amplification hosts of CHIKV. Additional efforts are needed to identify other hosts capable of supporting continuous circulation.
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U2 - 10.1038/s41467-018-03332-7
DO - 10.1038/s41467-018-03332-7
M3 - Article
C2 - 29535306
AN - SCOPUS:85044175339
SN - 2041-1723
VL - 9
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 1046
ER -