Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal

Benjamin M. Althouse, Mathilde Guerbois, Derek A.T. Cummings, Ousmane M. Diop, Ousmane Faye, Abdourahmane Faye, Diawo Diallo, Bakary Djilocalisse Sadio, Abdourahmane Sow, Oumar Faye, Amadou A. Sall, Mawlouth Diallo, Brenda Benefit, Evan Simons, Douglas M. Watts, Scott Weaver, Kathryn A. Hanley

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kédougou, Senegal. Over 3 years, 737 monkeys were captured, aged using anthropometry and dentition, and tested for exposure to CHIKV by detection of neutralizing antibodies. Infant monkeys were positive for CHIKV even when the virus was not detected in a concurrent survey of mosquitoes and when population immunity was too high for monkeys alone to support continuous transmission. We conclude that monkeys in this region serve as amplification hosts of CHIKV. Additional efforts are needed to identify other hosts capable of supporting continuous circulation.

Original languageEnglish (US)
Article number1046
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2018

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Senegal
Chikungunya virus
monkeys
viruses
Viruses
Haplorhini
cycles
Amplification
Arboviruses
anthropometry
Anthropometry
Dentition
immunity
Neutralizing Antibodies
Culicidae
antibodies
Immunity
Population

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Althouse, B. M., Guerbois, M., Cummings, D. A. T., Diop, O. M., Faye, O., Faye, A., ... Hanley, K. A. (2018). Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal. Nature Communications, 9(1), [1046]. https://doi.org/10.1038/s41467-018-03332-7

Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal. / Althouse, Benjamin M.; Guerbois, Mathilde; Cummings, Derek A.T.; Diop, Ousmane M.; Faye, Ousmane; Faye, Abdourahmane; Diallo, Diawo; Sadio, Bakary Djilocalisse; Sow, Abdourahmane; Faye, Oumar; Sall, Amadou A.; Diallo, Mawlouth; Benefit, Brenda; Simons, Evan; Watts, Douglas M.; Weaver, Scott; Hanley, Kathryn A.

In: Nature Communications, Vol. 9, No. 1, 1046, 01.12.2018.

Research output: Contribution to journalArticle

Althouse, BM, Guerbois, M, Cummings, DAT, Diop, OM, Faye, O, Faye, A, Diallo, D, Sadio, BD, Sow, A, Faye, O, Sall, AA, Diallo, M, Benefit, B, Simons, E, Watts, DM, Weaver, S & Hanley, KA 2018, 'Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal', Nature Communications, vol. 9, no. 1, 1046. https://doi.org/10.1038/s41467-018-03332-7
Althouse BM, Guerbois M, Cummings DAT, Diop OM, Faye O, Faye A et al. Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal. Nature Communications. 2018 Dec 1;9(1). 1046. https://doi.org/10.1038/s41467-018-03332-7
Althouse, Benjamin M. ; Guerbois, Mathilde ; Cummings, Derek A.T. ; Diop, Ousmane M. ; Faye, Ousmane ; Faye, Abdourahmane ; Diallo, Diawo ; Sadio, Bakary Djilocalisse ; Sow, Abdourahmane ; Faye, Oumar ; Sall, Amadou A. ; Diallo, Mawlouth ; Benefit, Brenda ; Simons, Evan ; Watts, Douglas M. ; Weaver, Scott ; Hanley, Kathryn A. / Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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