Role of mucosal mast cells in visceral hypersensitivity in a rat model of irritable bowel syndrome.

Jun Ho La, Tae Wan Kim, Tae Sik Sung, Hyun Ju Kim, Jeom Yong Kim, Il Suk Yang

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47 Scopus citations


The involvement of mucosal mast cells (MMC) in the pathophysiology of irritable bowel syndrome (IBS) is still controversial. We aimed to re-evaluate the role of MMC in visceral hypersensitivity associated with IBS using a rat IBS model that develops the IBS symptom after a subsidence of acetic acid-induced colitis. No significant difference in the number of MMC was observed between normal rat colon and IBS rat colon. (61.7 +/- 2.9/mm(2) in normal vs. 88.7 +/- 13.3/mm(2) in IBS, p > 0.29). However, the degranulation rate of MMC was significantly higher in IBS rat colon (49.5 +/- 2.4% in normal vs. 68.8 +/- 3.4% in IBS, p < 0.05). Pretreatment of a mast cell stabilizer, doxantrazole (5 mg/kg, i.p.), reduced the degranulation rate of MMC and significantly attenuated visceral hypersensitivity to rectal distension in IBS rat, whereas it had no effect on the visceral sensory responses in normal rat. These results suggest that, although the number of MMC is not significantly changed in IBS rat colon, the higher degranulation rate of MMC is responsible for visceral hypersensitivity in this model IBS.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalJournal of veterinary science (Suwon-si, Korea)
Issue number4
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus subject areas

  • General Veterinary


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