Role of nerve growth factor in oxidant‐antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

G. R. Jackson, L. Apffel, K. Werrbach‐Perez, J. R. Perez‐Polo

    Research output: Contribution to journalArticle

    155 Scopus citations

    Abstract

    The nerve growth factor protein (NGF) regulates neuronal cell death during the development of embryonic sensory and sympathetic neurons in the peripheral nervous system (PNS). NGF protects the rat pheochromocytoma line PC12, a useful model of NGF responsive peripheral neurons, from hydrogen peroxide, which interacts with ferrous iron to generate hydroxyl radicals. Exogenous catalase provides protection, whereas superoxide dismutase (SOD) has no effect on neuronal survival when PC12 cells are challenged with hydrogen peroxide. NGF treatment of PC12 cells increases the activity of catalase. NGF protection from hydrogen peroxide is partially abolished by aminotriazole (Az), a low molecular weight catalase inhibitor. Taken together, these data are consistent with the hypothesis that NGF protects from peroxidative events and consequent cell death via an induction of free radical detoxifying mechanisms, such as catalase activity.

    Original languageEnglish (US)
    Pages (from-to)360-368
    Number of pages9
    JournalJournal of Neuroscience Research
    Volume25
    Issue number3
    DOIs
    StatePublished - Mar 1990

    Keywords

    • NGF
    • catalase
    • cell death
    • free radicals
    • regeneration

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience

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