Role of nitric oxide in hemorrhagic shock

H. Ogata, X. X. Luo, Csaba Szabo, C. Thiemermann

Research output: Contribution to journalArticle

Abstract

It is stated in this article that the free radical nitric oxide is synthesized from enzymes termed the constitutive and inducible NO synthase and cellular intoxication of NO as well as the pathophysiology of hemorrhagic shock in relating to NO. Recent studies suggest that NO is responsible to irreversible from reversible shock owing to adhesion of PMN in the vascular endothelium. Insufficiency of the vascular endothelium loses ability of vasodilatation in brain, kidney, coronary vessels. The mechanism of vascular inability is not clarified yet, but PAF may be involved in. No produced from constitutive NOS prevents adhesion of PMN as well as platelet and produces vasodilatation. NO produced from inducible NOS observed in the late stage of hemorrhagic shock induces cytotoxic effects and leads to circulatory decompensation. Inducible NOS suppresses cardiac muscles and the injuries are prevented by L-NMMA or dexamethasone. Finally NOS inhibitors and NO related to traumatic, anaphylactic, and thermal injury are stated.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalAnesthesia and Resuscitation
Volume32
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Hemorrhagic Shock
Vascular Endothelium
Vasodilation
Nitric Oxide
omega-N-Methylarginine
Wounds and Injuries
Nitric Oxide Synthase
Dexamethasone
Free Radicals
Blood Vessels
Shock
Coronary Vessels
Myocardium
Blood Platelets
Hot Temperature
Kidney
Brain
Enzymes

Keywords

  • hemorrhagic shock
  • nitric oxide

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Ogata, H., Luo, X. X., Szabo, C., & Thiemermann, C. (1996). Role of nitric oxide in hemorrhagic shock. Anesthesia and Resuscitation, 32(1), 19-27.

Role of nitric oxide in hemorrhagic shock. / Ogata, H.; Luo, X. X.; Szabo, Csaba; Thiemermann, C.

In: Anesthesia and Resuscitation, Vol. 32, No. 1, 1996, p. 19-27.

Research output: Contribution to journalArticle

Ogata, H, Luo, XX, Szabo, C & Thiemermann, C 1996, 'Role of nitric oxide in hemorrhagic shock', Anesthesia and Resuscitation, vol. 32, no. 1, pp. 19-27.
Ogata H, Luo XX, Szabo C, Thiemermann C. Role of nitric oxide in hemorrhagic shock. Anesthesia and Resuscitation. 1996;32(1):19-27.
Ogata, H. ; Luo, X. X. ; Szabo, Csaba ; Thiemermann, C. / Role of nitric oxide in hemorrhagic shock. In: Anesthesia and Resuscitation. 1996 ; Vol. 32, No. 1. pp. 19-27.
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