Role of PD-L1 and PD-L2 in allergic diseases and asthma

A. K. Singh, P. Stock, O. Akbari

Research output: Contribution to journalReview article

68 Scopus citations

Abstract

Asthma is the result of chronic airway inflammation associated predominantly with CD4+ cells, eosinophils, mast cells, and basophils. Several T-cells subsets, including NKT cells, play a critical role in orchestrating the inflammation in the airways predominantly, by secreting interleukin-4 and interleukin-13. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was shown to regulate T-cell activation and tolerance. PD-1 has been characterized as a negative regulator of conventional CD4+T cells. In addition, the relative roles of PD-L1 and PD-L2 in regulating the activation and function of T cells have recently been characterized. Recent studies have demonstrated that PD-L1 and PD-L2 have important but opposing roles in modulating and polarizing T-cell functions in airway hyperreactivity. Whereas the severity of asthma is greatly enhanced in absence of PD-L2, PD-L1 deficiency resulted in reduced airway hyperresponsiveness and only minimal inflammation. This observation is partially because of the polarization of NKT cells in PD-L1- and PD-L2-deficient mice. This review will discuss the recent literature regarding the role of PD-L1 and PD-L2 in allergic disease and asthma. Current understanding of the role of PD ligands in allergic asthma gives impetus to the development of novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)155-162
Number of pages8
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume66
Issue number2
DOIs
StatePublished - Feb 1 2011

Keywords

  • asthma
  • programmed death ligand 1
  • programmed death ligand 2
  • programmed death-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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