Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes

Pál Pacher, Csaba Szabó

    Research output: Contribution to journalReview article

    121 Scopus citations

    Abstract

    Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to increased polyol pathway flux, activation of protein kinase C and accelerated non-enzymatic formation of advanced glycation end products. Many of these pathways become activated in response to the production of superoxide anion. Superoxide can interact with nitric oxide, forming the potent cytotoxin peroxynitrite. Peroxynitrite attacks various biomolecules in the vascular endothelium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via multiple mechanisms. This review focuses on emerging evidence suggesting that peroxynitrite plays a key role in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic retinopathy, neuropathy and nephropathy.

    Original languageEnglish (US)
    Pages (from-to)136-141
    Number of pages6
    JournalCurrent Opinion in Pharmacology
    Volume6
    Issue number2
    DOIs
    StatePublished - Apr 2006

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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