Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes

Pál Pacher, Csaba Szabo

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to increased polyol pathway flux, activation of protein kinase C and accelerated non-enzymatic formation of advanced glycation end products. Many of these pathways become activated in response to the production of superoxide anion. Superoxide can interact with nitric oxide, forming the potent cytotoxin peroxynitrite. Peroxynitrite attacks various biomolecules in the vascular endothelium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via multiple mechanisms. This review focuses on emerging evidence suggesting that peroxynitrite plays a key role in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic retinopathy, neuropathy and nephropathy.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume6
Issue number2
DOIs
StatePublished - Apr 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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