Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes

Pál Pacher, Csaba Szabo

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Hyperglycemic episodes, which complicate even well-controlled cases of diabetes, lead to increased polyol pathway flux, activation of protein kinase C and accelerated non-enzymatic formation of advanced glycation end products. Many of these pathways become activated in response to the production of superoxide anion. Superoxide can interact with nitric oxide, forming the potent cytotoxin peroxynitrite. Peroxynitrite attacks various biomolecules in the vascular endothelium, vascular smooth muscle and myocardium, eventually leading to cardiovascular dysfunction via multiple mechanisms. This review focuses on emerging evidence suggesting that peroxynitrite plays a key role in the pathogenesis of the cardiovascular complications of diabetes, which underlie the development and progression of diabetic retinopathy, neuropathy and nephropathy.

Original languageEnglish (US)
Pages (from-to)136-141
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume6
Issue number2
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Peroxynitrous Acid
Diabetes Complications
Superoxides
Advanced Glycosylation End Products
Diabetic Neuropathies
Cytotoxins
Vascular Endothelium
Diabetic Nephropathies
Diabetic Retinopathy
Vascular Smooth Muscle
Protein Kinase C
Myocardium
Nitric Oxide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. / Pacher, Pál; Szabo, Csaba.

In: Current Opinion in Pharmacology, Vol. 6, No. 2, 04.2006, p. 136-141.

Research output: Contribution to journalArticle

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