Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

David Walker, W. T. Firth, J. G. Ballard, B. C. Hegarty

Research output: Contribution to journalArticle

42 Scopus citations


The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.

Original languageEnglish (US)
Pages (from-to)840-842
Number of pages3
JournalInfection and Immunity
Issue number2
StatePublished - 1983
Externally publishedYes


ASJC Scopus subject areas

  • Immunology

Cite this