Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

David Walker, W. T. Firth, J. G. Ballard, B. C. Hegarty

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.

Original languageEnglish (US)
Pages (from-to)840-842
Number of pages3
JournalInfection and Immunity
Volume40
Issue number2
StatePublished - 1983
Externally publishedYes

Fingerprint

Rickettsia rickettsii
Phospholipases
Phentermine
Drug Receptors
Digitonin
Wounds and Injuries
Amphotericin B
Cholesterol

ASJC Scopus subject areas

  • Immunology

Cite this

Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii. / Walker, David; Firth, W. T.; Ballard, J. G.; Hegarty, B. C.

In: Infection and Immunity, Vol. 40, No. 2, 1983, p. 840-842.

Research output: Contribution to journalArticle

Walker, David ; Firth, W. T. ; Ballard, J. G. ; Hegarty, B. C. / Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii. In: Infection and Immunity. 1983 ; Vol. 40, No. 2. pp. 840-842.
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