Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

D. H. Walker; W. T. Firth; J. G. Ballard; B. C. Hegarty

doi:10.1128/iai.40.2.840-842.1983

Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

D. H. Walker, W. T. Firth, J. G. Ballard, B. C. Hegarty

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.

Original language	English (US)
Pages (from-to)	840-842
Number of pages	3
Journal	Infection and immunity
Volume	40
Issue number	2
DOIs	https://doi.org/10.1128/iai.40.2.840-842.1983
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/iai.40.2.840-842.1983

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abstract = "The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.",

author = "Walker, {D. H.} and Firth, {W. T.} and Ballard, {J. G.} and Hegarty, {B. C.}",

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AU - Hegarty, B. C.

PY - 1983

Y1 - 1983

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AB - The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.

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ER -

Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

Abstract

ASJC Scopus subject areas

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