Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

D. H. Walker; W. T. Firth; J. G. Ballard; B. C. Hegarty

doi:10.1128/iai.40.2.840-842.1983

Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

D. H. Walker
, W. T. Firth
, J. G. Ballard
, B. C. Hegarty

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.

Original language	English (US)
Pages (from-to)	840-842
Number of pages	3
Journal	Infection and immunity
Volume	40
Issue number	2
DOIs	https://doi.org/10.1128/iai.40.2.840-842.1983
State	Published - 1983
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/iai.40.2.840-842.1983

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title = "Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii",

abstract = "The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.",

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AU - Ballard, J. G.

AU - Hegarty, B. C.

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Y1 - 1983

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AB - The cholesterol receptor-binding drugs amphotericin B and digitonin reduced rickettsial plaque formation, presumably by blocking rickettsial attachment, even when added to the plaque model on day 4 post-inoculation when infected foci were well established. The phospholipase inhibitor phentermine reduced plaque formation, presumably by inhibiting the phospholipase-associated entry step of penetration.

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UR - https://www.scopus.com/pages/publications/0020585401#tab=citedBy

U2 - 10.1128/iai.40.2.840-842.1983

DO - 10.1128/iai.40.2.840-842.1983

M3 - Article

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AN - SCOPUS:0020585401

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JO - Infection and immunity

JF - Infection and immunity

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ER -

Role of phospholipase-associated penetration mechanism in cell injury by Rickettsia rickettsii

Abstract

ASJC Scopus subject areas

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