Role of pollen NAD(P)H oxidase in allergic inflammation

Nilesh Dharajiya, Istvan Boldogh, Victor Cardenas, Sanjiv Sur

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Plant pollens are one of the most common outdoor allergens. Pollen grains and subpollen particles can reach lower airways and induce symptoms of seasonal asthma and allergic rhinitis. Plants possess NAD(P)H oxidase activity that generates reactive oxygen species for physiological functions such as root-hair and pollen-tube growth, defense against microbial infections and cell signaling. The presence of NAD(P)H oxidases in pollens and their role in induction of airway inflammation have not been described until recently. RECENT FINDINGS: We discovered the presence of NAD(P)H oxidase in ragweed and other plant pollens. These oxidases induce reactive oxygen species in mucosal cells (signal 1) independent of adaptive immunity. This reactive oxygen species facilitates antigen (signal 2)-induced allergic inflammation. Inhibiting signal 1 by administration of antioxidants attenuated ragweed extract-induced allergic inflammation. Likewise, abrogating signal 2 by antigen challenge in mice lacking T cells failed to induce allergic inflammation. SUMMARY: Reactive oxygen species generated by pollen NAD(P)H oxidase play a major role in pathogenesis of allergic airway inflammation and airway hypersensitivity. Based on our findings, we propose a 'two signal hypothesis of allergic inflammation' in which both signal 1 (reactive oxygen species) and signal 2 (antigen presentation) are required in order to induce full-blown allergic inflammation.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume8
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

NADPH Oxidase
Pollen
Inflammation
Reactive Oxygen Species
Ambrosia
Pollen Tube
Antigens
Seasonal Allergic Rhinitis
Antigen Presentation
Adaptive Immunity
Hair
Allergens
Oxidoreductases
Hypersensitivity
Asthma
Antioxidants
T-Lymphocytes
Growth
Infection

Keywords

  • Airway inflammation
  • NAD(P)H oxidase
  • Reactive oxygen species

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Role of pollen NAD(P)H oxidase in allergic inflammation. / Dharajiya, Nilesh; Boldogh, Istvan; Cardenas, Victor; Sur, Sanjiv.

In: Current Opinion in Allergy and Clinical Immunology, Vol. 8, No. 1, 02.2008, p. 57-62.

Research output: Contribution to journalArticle

Dharajiya, Nilesh ; Boldogh, Istvan ; Cardenas, Victor ; Sur, Sanjiv. / Role of pollen NAD(P)H oxidase in allergic inflammation. In: Current Opinion in Allergy and Clinical Immunology. 2008 ; Vol. 8, No. 1. pp. 57-62.
@article{df974b7c2e674e17871f46b31440d923,
title = "Role of pollen NAD(P)H oxidase in allergic inflammation",
abstract = "PURPOSE OF REVIEW: Plant pollens are one of the most common outdoor allergens. Pollen grains and subpollen particles can reach lower airways and induce symptoms of seasonal asthma and allergic rhinitis. Plants possess NAD(P)H oxidase activity that generates reactive oxygen species for physiological functions such as root-hair and pollen-tube growth, defense against microbial infections and cell signaling. The presence of NAD(P)H oxidases in pollens and their role in induction of airway inflammation have not been described until recently. RECENT FINDINGS: We discovered the presence of NAD(P)H oxidase in ragweed and other plant pollens. These oxidases induce reactive oxygen species in mucosal cells (signal 1) independent of adaptive immunity. This reactive oxygen species facilitates antigen (signal 2)-induced allergic inflammation. Inhibiting signal 1 by administration of antioxidants attenuated ragweed extract-induced allergic inflammation. Likewise, abrogating signal 2 by antigen challenge in mice lacking T cells failed to induce allergic inflammation. SUMMARY: Reactive oxygen species generated by pollen NAD(P)H oxidase play a major role in pathogenesis of allergic airway inflammation and airway hypersensitivity. Based on our findings, we propose a 'two signal hypothesis of allergic inflammation' in which both signal 1 (reactive oxygen species) and signal 2 (antigen presentation) are required in order to induce full-blown allergic inflammation.",
keywords = "Airway inflammation, NAD(P)H oxidase, Reactive oxygen species",
author = "Nilesh Dharajiya and Istvan Boldogh and Victor Cardenas and Sanjiv Sur",
year = "2008",
month = "2",
doi = "10.1097/ACI.0b013e3282f3b5dc",
language = "English (US)",
volume = "8",
pages = "57--62",
journal = "Current Opinion in Allergy and Clinical Immunology",
issn = "1528-4050",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Role of pollen NAD(P)H oxidase in allergic inflammation

AU - Dharajiya, Nilesh

AU - Boldogh, Istvan

AU - Cardenas, Victor

AU - Sur, Sanjiv

PY - 2008/2

Y1 - 2008/2

N2 - PURPOSE OF REVIEW: Plant pollens are one of the most common outdoor allergens. Pollen grains and subpollen particles can reach lower airways and induce symptoms of seasonal asthma and allergic rhinitis. Plants possess NAD(P)H oxidase activity that generates reactive oxygen species for physiological functions such as root-hair and pollen-tube growth, defense against microbial infections and cell signaling. The presence of NAD(P)H oxidases in pollens and their role in induction of airway inflammation have not been described until recently. RECENT FINDINGS: We discovered the presence of NAD(P)H oxidase in ragweed and other plant pollens. These oxidases induce reactive oxygen species in mucosal cells (signal 1) independent of adaptive immunity. This reactive oxygen species facilitates antigen (signal 2)-induced allergic inflammation. Inhibiting signal 1 by administration of antioxidants attenuated ragweed extract-induced allergic inflammation. Likewise, abrogating signal 2 by antigen challenge in mice lacking T cells failed to induce allergic inflammation. SUMMARY: Reactive oxygen species generated by pollen NAD(P)H oxidase play a major role in pathogenesis of allergic airway inflammation and airway hypersensitivity. Based on our findings, we propose a 'two signal hypothesis of allergic inflammation' in which both signal 1 (reactive oxygen species) and signal 2 (antigen presentation) are required in order to induce full-blown allergic inflammation.

AB - PURPOSE OF REVIEW: Plant pollens are one of the most common outdoor allergens. Pollen grains and subpollen particles can reach lower airways and induce symptoms of seasonal asthma and allergic rhinitis. Plants possess NAD(P)H oxidase activity that generates reactive oxygen species for physiological functions such as root-hair and pollen-tube growth, defense against microbial infections and cell signaling. The presence of NAD(P)H oxidases in pollens and their role in induction of airway inflammation have not been described until recently. RECENT FINDINGS: We discovered the presence of NAD(P)H oxidase in ragweed and other plant pollens. These oxidases induce reactive oxygen species in mucosal cells (signal 1) independent of adaptive immunity. This reactive oxygen species facilitates antigen (signal 2)-induced allergic inflammation. Inhibiting signal 1 by administration of antioxidants attenuated ragweed extract-induced allergic inflammation. Likewise, abrogating signal 2 by antigen challenge in mice lacking T cells failed to induce allergic inflammation. SUMMARY: Reactive oxygen species generated by pollen NAD(P)H oxidase play a major role in pathogenesis of allergic airway inflammation and airway hypersensitivity. Based on our findings, we propose a 'two signal hypothesis of allergic inflammation' in which both signal 1 (reactive oxygen species) and signal 2 (antigen presentation) are required in order to induce full-blown allergic inflammation.

KW - Airway inflammation

KW - NAD(P)H oxidase

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=38049129664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049129664&partnerID=8YFLogxK

U2 - 10.1097/ACI.0b013e3282f3b5dc

DO - 10.1097/ACI.0b013e3282f3b5dc

M3 - Article

VL - 8

SP - 57

EP - 62

JO - Current Opinion in Allergy and Clinical Immunology

JF - Current Opinion in Allergy and Clinical Immunology

SN - 1528-4050

IS - 1

ER -