Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: The therapeutic potential of PARP inhibitors

Pharmacology, Toxicology and Pharmaceutical Science

• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor 100%
• Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1 100%
• Cardiovascular Disease 100%
• Atherosclerosis 50%
• Congestive Heart Failure 50%
• Heart Ventricle Hypertrophy 50%
• Myocardial Ischemia Reperfusion Injury 50%
• Vascular Remodeling 50%
• Myocardial Disease 50%
• Malignant Neoplasm 25%
• Reactive Oxygen Metabolite 25%
• Vitamin D 25%
• Purine Derivative 25%
• Therapeutic Effect 25%
• Knockout Mouse 25%
• Diabetic Complication 25%
• Adenosine Triphosphate 25%
• Reactive Nitrogen Species 25%
• Functional Disease 25%
• Polyamine 25%
• Thyroid Hormone 25%
• Anticancer Drug 25%

Keyphrases

• Cardiovascular Disease 100%
• Therapeutic Potential 100%
• PARP Inhibitor (PARPi) 100%
• Cardiomyopathy 25%
• Endothelial Cells 25%
• Cardiomyocytes 25%
• Circulatory Shock 25%
• Myocardial Hypertrophy 25%
• Cardiovascular Aging 25%
• Angiogenesis 25%
• Heart Failure 25%
• Myocardial Ischemia-reperfusion Injury 25%
• Vascular Remodeling 25%
• Cancer Treatment 12%
• Knock-in Mouse Model 12%
• Reactive Oxygen Species 12%
• Vitamin D 12%
• Purine 12%
• Estrogen 12%
• Pharmacological Inhibitors 12%
• Therapeutic Effect 12%
• Diabetes Complications 12%
• Diabetic Vascular Complications 12%
• Reactive Species 12%
• Glycolysis 12%
• Reactive Nitrogen Species 12%
• Inflammatory Pathways 12%
• Anticancer Drugs 12%
• Thyroid Hormones 12%
• Oxidative DNA Damage 12%
• Nicotinamide Adenine Dinucleotide (NAD+) 12%
• Functional Impairment 12%
• Electron Transport 12%
• PARP Activation 12%
• Endogenous Factors 12%
• Polyamines 12%
• Overactivation 12%
• Significant Benefit 12%
• Clinical Development 12%
• ATP Formation 12%
• Enzyme Family 12%
• PARP Enzymes 12%