Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis

G. S. Scott, P. Hake, R. B. Kean, L. Virág, Csaba Szabo, D. C. Hooper

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the development of EAE. Administration of the PARS inhibitor 5-iodo-6-amino-1,2-benzopyrone (INH2BP) delayed the onset of EAE and reduced the incidence and severity of disease signs. Moreover, drug treatment lowered iNOS activity and decreased cell infiltration in cervical spinal tissues from EAE-sensitized animals. To conclude, the results of the present investigation suggest that PARS activity may contribute to the pathogenesis of EAE.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalJournal of Neuroimmunology
Volume117
Issue number1-2
DOIs
StatePublished - Jul 2 2001
Externally publishedYes

Fingerprint

Poly Adenosine Diphosphate Ribose
Autoimmune Experimental Encephalomyelitis
Ligases
Peroxynitrous Acid
Incidence
Enzymes
Pharmaceutical Preparations

Keywords

  • Blood-brain barrier
  • Experimental allergic encephalomyelitis
  • Inflammation
  • Peroxynitrite
  • Poly(ADP-ribose) synthetase

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. / Scott, G. S.; Hake, P.; Kean, R. B.; Virág, L.; Szabo, Csaba; Hooper, D. C.

In: Journal of Neuroimmunology, Vol. 117, No. 1-2, 02.07.2001, p. 78-86.

Research output: Contribution to journalArticle

Scott, G. S. ; Hake, P. ; Kean, R. B. ; Virág, L. ; Szabo, Csaba ; Hooper, D. C. / Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis. In: Journal of Neuroimmunology. 2001 ; Vol. 117, No. 1-2. pp. 78-86.
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