Abstract
Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the development of EAE. Administration of the PARS inhibitor 5-iodo-6-amino-1,2-benzopyrone (INH2BP) delayed the onset of EAE and reduced the incidence and severity of disease signs. Moreover, drug treatment lowered iNOS activity and decreased cell infiltration in cervical spinal tissues from EAE-sensitized animals. To conclude, the results of the present investigation suggest that PARS activity may contribute to the pathogenesis of EAE.
Original language | English (US) |
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Pages (from-to) | 78-86 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 117 |
Issue number | 1-2 |
DOIs | |
State | Published - Jul 2 2001 |
Externally published | Yes |
Keywords
- Blood-brain barrier
- Experimental allergic encephalomyelitis
- Inflammation
- Peroxynitrite
- Poly(ADP-ribose) synthetase
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology