Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis

G. S. Scott, P. Hake, R. B. Kean, L. Virág, C. Szabó, D. C. Hooper

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    Abstract

    Peroxynitrite formation has been demonstrated during experimental allergic encephalomyelitis (EAE). Furthermore, peroxynitrite has been identified as an activator of poly(ADP-ribose) synthetase (PARS), an enzyme implicated in neurotoxicity. In the current study, we examined the role of PARS activation in the development of EAE. Administration of the PARS inhibitor 5-iodo-6-amino-1,2-benzopyrone (INH2BP) delayed the onset of EAE and reduced the incidence and severity of disease signs. Moreover, drug treatment lowered iNOS activity and decreased cell infiltration in cervical spinal tissues from EAE-sensitized animals. To conclude, the results of the present investigation suggest that PARS activity may contribute to the pathogenesis of EAE.

    Original languageEnglish (US)
    Pages (from-to)78-86
    Number of pages9
    JournalJournal of Neuroimmunology
    Volume117
    Issue number1-2
    DOIs
    StatePublished - Jul 2 2001

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    Keywords

    • Blood-brain barrier
    • Experimental allergic encephalomyelitis
    • Inflammation
    • Peroxynitrite
    • Poly(ADP-ribose) synthetase

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Neurology
    • Clinical Neurology

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