Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes

Keyphrases

• 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 16%
• Allelic Variants 16%
• Blood Culture 16%
• Canter 16%
• Chromosomal Aberration Test 16%
• Chromosomal Aberrations 100%
• Concentration-dependent 16%
• CYP2D6 Genotype 100%
• CYP2D6 Inhibitor 16%
• CYP2D6 Poor Metabolizer 16%
• CYP2E1 Gene 100%
• CYP2E1 Inhibitor 16%
• CYP2E1 Polymorphism 16%
• Cytochrome P450 2D6 (CYP2D6) 50%
• Cytochrome P450 2E1 (CYP2E1) 66%
• Cytochrome P450 Enzymes 16%
• Cytochrome P450 Inhibitors 16%
• Diethyldithiocarbamate 16%
• Environmental Carcinogenesis 16%
• Environmental mutagen 16%
• Extensive Metabolizer 16%
• Genetic Damage 16%
• Genotoxic Agents 16%
• Genotoxicity 16%
• Genotype 33%
• Human Lymphocytes 100%
• In Situ Hybridization 16%
• Lung Cancer 16%
• Metabolic Activation 16%
• N-nitrosamines 16%
• Polymorphism 16%
• Quinidine 16%
• Reactive Intermediates 16%
• Whole Blood Culture 16%
• Xenobiotic Metabolizing Enzymes 16%

Pharmacology, Toxicology and Pharmaceutical Science

• 4 (Methylnitrosamino) 1 (3 Pyridyl) 1 Butanone 10%
• Chromosome Aberration 100%
• CYP2D6 100%
• CYP2E1 100%
• Cytochrome P450 10%
• Cytochrome P450 2D6 Inhibitor 10%
• Cytochrome P450 2E1 Inhibitor 10%
• Cytochrome P450 Inhibitor 10%
• Environmental Mutagen 10%
• Genotoxicity 10%
• Lung Cancer 10%
• Malignant Neoplasm 10%
• Nicotine-Derived Nitrosamine Ketone 100%
• Quinidine 10%
• Sodium Diethyldithiocarbamate 10%
• Tobacco-Specific Nitrosamines 10%
• Xenobiotic Agent 10%

Immunology and Microbiology

• Diethyldithiocarbamic Acid 50%
• Fluorescence in Situ Hybridization 50%
• Genetic Damage 50%
• Lymphocyte 100%
• Metabolic Activation 50%
• Xenobiotic 50%