Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis

Steven I. Wolinsky, James S. Goodwin, Ronald P. Messner, Ralph C. Williams

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Peripheral blood mononuclear cells from patients with rheumatoid arthritis have a depressed response to phytohemagglutinin in vitro. This depression was partly reversed by adding indomethacin, a prostaglandin synthetase inhibitor, to the cultures. Removal of glass-adherent cells prior to culture did not affect the depressed mitogen response of the patients' cells. The phytohemagglutinin response of peripheral blood mononuclear cells from rheumatoid arthritis patients was more sensitive than normal to inhibition by exogenous prostaglandin E2.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalClinical Immunology and Immunopathology
Volume17
Issue number1
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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