Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis

S. I. Wolinsky, James Goodwin, R. P. Messner, R. C. Williams

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Peripheral blood mononuclear cells from patients with rheumatoid arthritis have a depressed response to phytohemagglutinin in vitro. This depression was partly reversed by adding indomethacin, a prostaglandin synthetase inhibitor, to the cultures. Removal of glass-adherent cells prior to culture did not affect the depressed mitogen response of the patients' cells. The phytohemagglutinin response of peripheral blood mononuclear cells from rheumatoid arthritis patients was more sensitive than normal to inhibition by exogenous prostaglandin E2.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalClinical Immunology and Immunopathology
Volume17
Issue number1
StatePublished - 1980
Externally publishedYes

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Prostaglandins
Rheumatoid Arthritis
Phytohemagglutinins
Blood Cells
Prostaglandin Antagonists
Prostaglandin-Endoperoxide Synthases
Mitogens
Dinoprostone
Indomethacin
Glass
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Role of prostaglandin in the depressed cell-mediated immune response in rheumatoid arthritis. / Wolinsky, S. I.; Goodwin, James; Messner, R. P.; Williams, R. C.

In: Clinical Immunology and Immunopathology, Vol. 17, No. 1, 1980, p. 31-37.

Research output: Contribution to journalArticle

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