Role of prostaglandins and cAMP in the secretory effects of cholera toxin

Johnny Peterson, Laura G. Ochoa

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The role of adenosine 3′,5′-monophosphate (cAMP) and prostaglandins in the pathogenesis of experimental cholera was evaluated. Fluid accumulated in the rabbit intestinal loop model after 16 hours of incubation with cholera toxin, prostaglandin E1, or prostaglandin E2, but not with membrane-permeable derivatives of cAMP or forskolin. Dibutryl cAMP triggered a small, transient intestinal fluid accumulation response by 4.5 hours; however, the fluid was completely absorbed by 9 hours. After exposure of intestinal loops to cholera toxin, prostaglandin E was released into the intestinal lumen in a concentration-dependent manner independent of cAMP. Thus, not only cAMP, but also prostaglandins may regulate water and electrolyte secretion in cholera.

Original languageEnglish (US)
Pages (from-to)857-859
Number of pages3
JournalScience
Volume245
Issue number4920
StatePublished - 1989

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Cholera
Cholera Toxin
Prostaglandins
Alprostadil
Colforsin
Prostaglandins E
Dinoprostone
Adenosine
Electrolytes
Rabbits
Membranes
Water

ASJC Scopus subject areas

  • General

Cite this

Role of prostaglandins and cAMP in the secretory effects of cholera toxin. / Peterson, Johnny; Ochoa, Laura G.

In: Science, Vol. 245, No. 4920, 1989, p. 857-859.

Research output: Contribution to journalArticle

Peterson, Johnny ; Ochoa, Laura G. / Role of prostaglandins and cAMP in the secretory effects of cholera toxin. In: Science. 1989 ; Vol. 245, No. 4920. pp. 857-859.
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