Role of Renin Classification for Diuretic Treatment of Black Hypertensive Patients

O. Bryan Holland, Celso Gomez Sanchez, Carol Fairchild, Norman M. Kaplan

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27 Scopus citations


Previous studies in white and mixed-race hypertensive patient populations have generally found patients with low renin activity more responsive to diuretic therapy than patients with normal renin activity. Twenty-nine black patients (26 women and three men) with placebo diastolic blood pressure of 90 to 115 mm Hg were treated with spironolactone (100 to 400 mg/day) and hydrochlorothiazide (100/mg/day). Renin status was categorized by (1) the intravenous furosemide test, (2) ambulation during placebo, and (3) ambulation during spironolactone and hydrochlorothiazide treatment. Only seven patients were categorized identically with all methods. No method identified a low renin subgroup that was more responsive to either spironolactone or hydrochlorothiazide. Diastolic blood pressure fall with hydrochlorothiazide (18 mm Hg) and 400 mg/day of spironolactone (15 mm Hg) was similar. Thus, since black women with both low and normal renin activity are quite responsive to diuretics, renin classification to guide initial antihypertensive selection is not warranted.

Original languageEnglish (US)
Pages (from-to)1365-1370
Number of pages6
JournalArchives of Internal Medicine
Issue number12
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Internal Medicine


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