Role of respiratory syncytial virus in acute otitis media: Implications for vaccine development

Janak Patel, Dang T. Nguyen, Krystal Revai, Tasnee Chonmaitree

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We summarize herein the results of various virologic studies of acute otitis media (AOM) conducted at our site over a 10-year period. Among 566 children with AOM, respiratory syncytial virus (RSV) was the most common virus identified in either middle ear fluid or nasal wash; it was found in 16% of all children and 38% of virus-positive children. Seventy-one percent of the children with RSV were 1 year of age or older, which was significantly older than all other viruses combined (P = 0.045). RSV infection was associated with the common bacterial pathogens causing AOM. Past efforts to develop vaccines for RSV have emphasized prevention of lower respiratory tract infection in infants, which is a more serious problem but less common than AOM. Our results suggest that RSV vaccines that work only against infection in older children may have value in preventing AOM, the most common pediatric disease.

Original languageEnglish (US)
Pages (from-to)1683-1689
Number of pages7
JournalVaccine
Volume25
Issue number9
DOIs
StatePublished - Feb 19 2007

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Keywords

  • Otitis media
  • Respiratory syncytial virus
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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