Role of silver nanoparticles (AgNPs) on the cardiovascular system

Carmen Gonzalez, Hector Rosas-Hernandez, Manuel Alejandro Ramirez-Lee, Samuel Salazar-García, Syed F. Ali

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


With the advent of nanotechnology, the use and applications of silver nanoparticles (AgNPs) have increased, both in consumer products as well as in medical devices. However, little is known about the effects of these nanoparticles on human health, more specific in the cardiovascular system, since this system represents an important route of action in terms of distribution, bioaccumulation and bioavailability of the different circulating substances in the bloodstream. A collection of studies have addressed the effects and applications of different kinds of AgNPs (shaped, sized, coated and functionalized) in several components of the cardiovascular system, such as endothelial cells, isolated vessels and organs as well as integrative animal models, trying to identify the underlying mechanisms involved in their actions, to understand their implication in the field of biomedicine. The purpose of the present review is to summarize the most relevant studies to date of AgNPs effects in the cardiovascular system and provide a broader picture of the potential toxic effects and exposure risks, which in turn will allow pointing out the directions of further research as well as new applications of these versatile nanomaterials.

Original languageEnglish (US)
Pages (from-to)493-511
Number of pages19
JournalArchives of Toxicology
Issue number3
StatePublished - Mar 1 2016
Externally publishedYes


  • Blood vessels
  • Cardiovascular system
  • Endothelium
  • Silver nanoparticles
  • Toxicity

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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