Role of taurine in feeding the low-birth-weightinfant

Emi Okamoto, David K. Rassin, Christine L. Zucker, Gerald S. Salen, William C. Heird

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Plasma and urinary taurine concentrations, growth, nitrogen balance, duodenal bile salt concentrationand pattern, fecal bile acid excretion, and intestinal fat absorption were determined in appropriate for gestational age low-birth-weight infants fed either a whey-predominant cow milk formula or the same formula supplemented with taurine (45 μmol/kg/day). Mean plasma taurine concentration in the two groups did not differ. Mean urinary taurine concentration in the control and supplemented groups over the entire study period were 2.67±0.69 and 12.41±5.20 μmol/dl, respectively (P<0.05). Urinary taurine concentration in the supplemented infants, however, decreased significantly during the study period. Neither growth nor nitrogen retention differed between the two groups. Mean duodenal concentrations of taurine as well as glycine conjugates of both cholate and chenodeoxycholate were higher in supplemented infants. Total duodenal bile salt concentration correlated positively with taurine status as reflected by urinary taurine excretion (r=0.71); this correlation plus the lower duodenal cholesterol concentration in supplemented infants suggests that conversion of cholesterol to bile acids was greater in supplemented infants. Mean intestinal fat absorption in control and supplemented infants, however, did not differ.

Original languageEnglish (US)
Pages (from-to)936-940
Number of pages5
JournalThe Journal of pediatrics
Volume104
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

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Taurine
Parturition
Bile Acids and Salts
Intestinal Absorption
Nitrogen
Fats
Cholesterol
Cholates
Chenodeoxycholic Acid
Low Birth Weight Infant
Growth
Glycine
Gestational Age
Milk
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Okamoto, E., Rassin, D. K., Zucker, C. L., Salen, G. S., & Heird, W. C. (1984). Role of taurine in feeding the low-birth-weightinfant. The Journal of pediatrics, 104(6), 936-940. https://doi.org/10.1016/S0022-3476(84)80503-X

Role of taurine in feeding the low-birth-weightinfant. / Okamoto, Emi; Rassin, David K.; Zucker, Christine L.; Salen, Gerald S.; Heird, William C.

In: The Journal of pediatrics, Vol. 104, No. 6, 1984, p. 936-940.

Research output: Contribution to journalArticle

Okamoto, E, Rassin, DK, Zucker, CL, Salen, GS & Heird, WC 1984, 'Role of taurine in feeding the low-birth-weightinfant', The Journal of pediatrics, vol. 104, no. 6, pp. 936-940. https://doi.org/10.1016/S0022-3476(84)80503-X
Okamoto, Emi ; Rassin, David K. ; Zucker, Christine L. ; Salen, Gerald S. ; Heird, William C. / Role of taurine in feeding the low-birth-weightinfant. In: The Journal of pediatrics. 1984 ; Vol. 104, No. 6. pp. 936-940.
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