TY - JOUR
T1 - Role of the aryl hydrocarbon receptor in cell cycle regulation
AU - Puga, Alvaro
AU - Xia, Ying
AU - Elferink, Cornelis
N1 - Funding Information:
Preparation of this review and the cited research performed in the authors' laboratories were supported in part by NIH Grants R01 ES06273, ES10807, and P30 ES06096 (AP) and R01 ES07800 (CJE).
PY - 2002/9/20
Y1 - 2002/9/20
N2 - Traditionally, the aryl hydrocarbon receptor (AHR) is considered to be a ligand-activated receptor and transcription factor responsible for the induction of drug-metabolizing enzymes. Its role in the combinatorial matrix of cell functions was neatly established long before the first report of an AHR cDNA sequence was published. Only recently, other functions of this protein have begun to be recognized. This review addresses novel findings relating to AHR functions that have resulted from experimental approaches markedly outside traditional receptor analyses. Here we examine the aspects of AHR biology relevant to its role in cell cycle regulation, from the activation of mitogen-activated protein kinases to the cross-talk between AHR and the RAS pathway and the functional significance of the interaction between AHR and the retinoblastoma protein. We have attempted to provide the reader with a balanced interpretation of the evidence, highlighting areas of consensus as well as areas still being contested.
AB - Traditionally, the aryl hydrocarbon receptor (AHR) is considered to be a ligand-activated receptor and transcription factor responsible for the induction of drug-metabolizing enzymes. Its role in the combinatorial matrix of cell functions was neatly established long before the first report of an AHR cDNA sequence was published. Only recently, other functions of this protein have begun to be recognized. This review addresses novel findings relating to AHR functions that have resulted from experimental approaches markedly outside traditional receptor analyses. Here we examine the aspects of AHR biology relevant to its role in cell cycle regulation, from the activation of mitogen-activated protein kinases to the cross-talk between AHR and the RAS pathway and the functional significance of the interaction between AHR and the retinoblastoma protein. We have attempted to provide the reader with a balanced interpretation of the evidence, highlighting areas of consensus as well as areas still being contested.
KW - Environmental checkpoints
KW - Gene regulation
KW - Polycyclic aromatic compounds
KW - Retinoblastoma protein
KW - Signal transduction
KW - Transcription factors
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U2 - 10.1016/S0009-2797(02)00069-8
DO - 10.1016/S0009-2797(02)00069-8
M3 - Article
C2 - 12213388
AN - SCOPUS:0037145022
SN - 0009-2797
VL - 141
SP - 117
EP - 130
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 1-2
ER -