Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine

S. Rehberg, P. Enkhbaatar, D. L. Traber

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The calcium (Ca2+)-sensitizer, levosimendan, is recommended by the European Heart Association and the European Society of Intensive Care Medicine for the treatment of low output heart failure, when standard treatment is insufficient [1]. Despite encouraging results from experimental and randomized clinical studies, a recent large randomized, double-blind, multicenter trial in patients with acute decompensated heart failure (Survival Of Patients With Acute Heart Failure In Need Of Intravenous Inotropic Support, SURVIVE study), did not reveal any significant reduction in 31- or 180-day mortality with levosimendan compared to dobutamine [2]. The elementary question that needs to be addressed and was recently elegantly worded by Dr. Butler and colleagues, is whether to abandon or not to abandon levosimendan? [3].

Original languageEnglish (US)
Title of host publicationYearbook of Intensive Care and Emergency Medicine 2009
PublisherSpringer New York
Pages498-510
Number of pages13
ISBN (Print)9780387922775
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine'. Together they form a unique fingerprint.

  • Cite this

    Rehberg, S., Enkhbaatar, P., & Traber, D. L. (2007). Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine. In Yearbook of Intensive Care and Emergency Medicine 2009 (pp. 498-510). Springer New York. https://doi.org/10.1007/978-0-387-92278-2_47