Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine

S. Rehberg, Perenlei Enkhbaatar, D. L. Traber

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The calcium (Ca2+)-sensitizer, levosimendan, is recommended by the European Heart Association and the European Society of Intensive Care Medicine for the treatment of low output heart failure, when standard treatment is insufficient [1]. Despite encouraging results from experimental and randomized clinical studies, a recent large randomized, double-blind, multicenter trial in patients with acute decompensated heart failure (Survival Of Patients With Acute Heart Failure In Need Of Intravenous Inotropic Support, SURVIVE study), did not reveal any significant reduction in 31- or 180-day mortality with levosimendan compared to dobutamine [2]. The elementary question that needs to be addressed and was recently elegantly worded by Dr. Butler and colleagues, is whether to abandon or not to abandon levosimendan? [3].

Original languageEnglish (US)
Title of host publicationYearbook of Intensive Care and Emergency Medicine 2009
PublisherSpringer New York
Pages498-510
Number of pages13
ISBN (Print)9780387922775
DOIs
StatePublished - 2007

Fingerprint

Perioperative Care
Critical Care
Heart Failure
Medicine
Calcium
Dobutamine
Multicenter Studies
Survival
Mortality
Therapeutics
simendan

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rehberg, S., Enkhbaatar, P., & Traber, D. L. (2007). Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine. In Yearbook of Intensive Care and Emergency Medicine 2009 (pp. 498-510). Springer New York. https://doi.org/10.1007/978-0-387-92278-2_47

Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine. / Rehberg, S.; Enkhbaatar, Perenlei; Traber, D. L.

Yearbook of Intensive Care and Emergency Medicine 2009. Springer New York, 2007. p. 498-510.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rehberg, S, Enkhbaatar, P & Traber, DL 2007, Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine. in Yearbook of Intensive Care and Emergency Medicine 2009. Springer New York, pp. 498-510. https://doi.org/10.1007/978-0-387-92278-2_47
Rehberg S, Enkhbaatar P, Traber DL. Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine. In Yearbook of Intensive Care and Emergency Medicine 2009. Springer New York. 2007. p. 498-510 https://doi.org/10.1007/978-0-387-92278-2_47
Rehberg, S. ; Enkhbaatar, Perenlei ; Traber, D. L. / Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine. Yearbook of Intensive Care and Emergency Medicine 2009. Springer New York, 2007. pp. 498-510
@inbook{0b581f3dd4a5442ba356984c434c70ac,
title = "Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine",
abstract = "The calcium (Ca2+)-sensitizer, levosimendan, is recommended by the European Heart Association and the European Society of Intensive Care Medicine for the treatment of low output heart failure, when standard treatment is insufficient [1]. Despite encouraging results from experimental and randomized clinical studies, a recent large randomized, double-blind, multicenter trial in patients with acute decompensated heart failure (Survival Of Patients With Acute Heart Failure In Need Of Intravenous Inotropic Support, SURVIVE study), did not reveal any significant reduction in 31- or 180-day mortality with levosimendan compared to dobutamine [2]. The elementary question that needs to be addressed and was recently elegantly worded by Dr. Butler and colleagues, is whether to abandon or not to abandon levosimendan? [3].",
author = "S. Rehberg and Perenlei Enkhbaatar and Traber, {D. L.}",
year = "2007",
doi = "10.1007/978-0-387-92278-2_47",
language = "English (US)",
isbn = "9780387922775",
pages = "498--510",
booktitle = "Yearbook of Intensive Care and Emergency Medicine 2009",
publisher = "Springer New York",

}

TY - CHAP

T1 - Role of the calcium sensitizer, levosimendan, in perioperative intensive care medicine

AU - Rehberg, S.

AU - Enkhbaatar, Perenlei

AU - Traber, D. L.

PY - 2007

Y1 - 2007

N2 - The calcium (Ca2+)-sensitizer, levosimendan, is recommended by the European Heart Association and the European Society of Intensive Care Medicine for the treatment of low output heart failure, when standard treatment is insufficient [1]. Despite encouraging results from experimental and randomized clinical studies, a recent large randomized, double-blind, multicenter trial in patients with acute decompensated heart failure (Survival Of Patients With Acute Heart Failure In Need Of Intravenous Inotropic Support, SURVIVE study), did not reveal any significant reduction in 31- or 180-day mortality with levosimendan compared to dobutamine [2]. The elementary question that needs to be addressed and was recently elegantly worded by Dr. Butler and colleagues, is whether to abandon or not to abandon levosimendan? [3].

AB - The calcium (Ca2+)-sensitizer, levosimendan, is recommended by the European Heart Association and the European Society of Intensive Care Medicine for the treatment of low output heart failure, when standard treatment is insufficient [1]. Despite encouraging results from experimental and randomized clinical studies, a recent large randomized, double-blind, multicenter trial in patients with acute decompensated heart failure (Survival Of Patients With Acute Heart Failure In Need Of Intravenous Inotropic Support, SURVIVE study), did not reveal any significant reduction in 31- or 180-day mortality with levosimendan compared to dobutamine [2]. The elementary question that needs to be addressed and was recently elegantly worded by Dr. Butler and colleagues, is whether to abandon or not to abandon levosimendan? [3].

UR - http://www.scopus.com/inward/record.url?scp=77957246033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957246033&partnerID=8YFLogxK

U2 - 10.1007/978-0-387-92278-2_47

DO - 10.1007/978-0-387-92278-2_47

M3 - Chapter

AN - SCOPUS:77957246033

SN - 9780387922775

SP - 498

EP - 510

BT - Yearbook of Intensive Care and Emergency Medicine 2009

PB - Springer New York

ER -