Role of the cholinergic system in the regulation of neurotrophin synthesis

Juan Yu, Donald P. Pizzo, Leslie A. Hutton, J. Regino Perez-Polo

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the family of neurotrophins that are highly expressed in the adult hippocampus, and to a lesser extent, in the cerebral cortex and olfactory bulb. Since neuronal expression of neurotrophins is controlled by some neurotransmitters and there is a topographical correlation between neurotrophin expression and cholinergic terminal distribution from the cholinergic basal forebrain (CBF) neurons in these areas, the question arises as to whether the cholinergic system can also regulate neurotrophin gene expression in the CNS. When CBF neurons were selectively and completely destroyed by intraventricular injection of 192 IgG-saporin, resulting in a cholinergic deafferentation of the hippocampus, cortex, and olfactory bulb, there were no siginificant changes in NGF, BDNF and/or NT-3 mRNA levels in these areas from 1 week to 5 months after the lesion. These results suggest that afferents from CBF neurons may not play a significant role in maintaining basal levels of neurotrophin gene expression in the adult rat brain under physiological conditions. However, potential cholinergic regulation of brain neurontrophin expression may occur under other circumstances.

    Original languageEnglish (US)
    Pages (from-to)247-254
    Number of pages8
    JournalBrain Research
    Volume705
    Issue number1-2
    DOIs
    StatePublished - Dec 24 1995

    Fingerprint

    Nerve Growth Factors
    Cholinergic Agents
    Neurotrophin 3
    Olfactory Bulb
    Brain-Derived Neurotrophic Factor
    Nerve Growth Factor
    Neurons
    Hippocampus
    Intraventricular Injections
    Gene Expression
    Brain
    Cerebral Cortex
    Neurotransmitter Agents
    Messenger RNA
    Basal Forebrain

    Keywords

    • Cholinergic basal forebrain neuron
    • Immunolesion
    • mRNA expression
    • Neurotrophin

    ASJC Scopus subject areas

    • Developmental Biology
    • Molecular Biology
    • Clinical Neurology
    • Neuroscience(all)

    Cite this

    Yu, J., Pizzo, D. P., Hutton, L. A., & Perez-Polo, J. R. (1995). Role of the cholinergic system in the regulation of neurotrophin synthesis. Brain Research, 705(1-2), 247-254. https://doi.org/10.1016/0006-8993(95)01169-2

    Role of the cholinergic system in the regulation of neurotrophin synthesis. / Yu, Juan; Pizzo, Donald P.; Hutton, Leslie A.; Perez-Polo, J. Regino.

    In: Brain Research, Vol. 705, No. 1-2, 24.12.1995, p. 247-254.

    Research output: Contribution to journalArticle

    Yu, J, Pizzo, DP, Hutton, LA & Perez-Polo, JR 1995, 'Role of the cholinergic system in the regulation of neurotrophin synthesis', Brain Research, vol. 705, no. 1-2, pp. 247-254. https://doi.org/10.1016/0006-8993(95)01169-2
    Yu, Juan ; Pizzo, Donald P. ; Hutton, Leslie A. ; Perez-Polo, J. Regino. / Role of the cholinergic system in the regulation of neurotrophin synthesis. In: Brain Research. 1995 ; Vol. 705, No. 1-2. pp. 247-254.
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