Role of the peroxynitrite - Poly (ADP-ribose) polymerase pathway in the pathogenesis of liver injury

Domokos Gero, Csaba Szabo

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Oxidative and nitrosative stress triggers DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) polymerase (PARP). One of the key triggers of DNA single strand breakage in pathophysiological conditions is peroxynitrite, a reactive species produced from the reaction of nitric oxide and superoxide. Activation of PARP can dramatically lower the intracellular concentration of its substrate, nicotinamide adenine dinucleotide, thus slowing the rate of glycolysis, electron transport and subsequently ATP formation. This process can result in cell dysfunction and cell death. Here we review the role of PARP in various forms of liver injury.

Original languageEnglish (US)
Pages (from-to)2903-2910
Number of pages8
JournalCurrent Pharmaceutical Design
Volume12
Issue number23
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Peroxynitrous Acid
Poly(ADP-ribose) Polymerases
Liver
Wounds and Injuries
DNA
Glycolysis
Electron Transport
Superoxides
NAD
Nitric Oxide
Oxidative Stress
Cell Death
Adenosine Triphosphate
Enzymes

Keywords

  • Hepatic
  • Liver
  • Nitric oxide
  • Peroxynitrite
  • Reperfusion
  • Sepsis
  • Superoxide

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Role of the peroxynitrite - Poly (ADP-ribose) polymerase pathway in the pathogenesis of liver injury. / Gero, Domokos; Szabo, Csaba.

In: Current Pharmaceutical Design, Vol. 12, No. 23, 08.2006, p. 2903-2910.

Research output: Contribution to journalArticle

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