Role of the peroxynitrite - Poly (ADP-ribose) polymerase pathway in the pathogenesis of liver injury

Domokos Gero, Csaba Szabó

    Research output: Contribution to journalReview articlepeer-review

    24 Scopus citations

    Abstract

    Oxidative and nitrosative stress triggers DNA strand breakage, which then activates the nuclear enzyme poly(ADP-ribose) polymerase (PARP). One of the key triggers of DNA single strand breakage in pathophysiological conditions is peroxynitrite, a reactive species produced from the reaction of nitric oxide and superoxide. Activation of PARP can dramatically lower the intracellular concentration of its substrate, nicotinamide adenine dinucleotide, thus slowing the rate of glycolysis, electron transport and subsequently ATP formation. This process can result in cell dysfunction and cell death. Here we review the role of PARP in various forms of liver injury.

    Original languageEnglish (US)
    Pages (from-to)2903-2910
    Number of pages8
    JournalCurrent Pharmaceutical Design
    Volume12
    Issue number23
    DOIs
    StatePublished - Aug 1 2006

    Keywords

    • Hepatic
    • Liver
    • Nitric oxide
    • Peroxynitrite
    • Reperfusion
    • Sepsis
    • Superoxide

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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