Role of virulence factors on host inflammatory response induced by diarrheagenic Escherichia coli pathotypes

Javier Sanchez-Villamil, Fernando Navarro-Garcia

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Pathogens are able to breach the intestinal barrier, and different bacterial species can display different abilities to colonize hosts and induce inflammation. Inflammatory response studies induced by enteropathogens as Escherichia coli are interesting since it has acquired diverse genetic mobile elements, leading to different E. Coli pathotypes. Diarrheagenic E. Coli secrete toxins, effectors and virulence factors that exploit the host cell functions to facilitate the bacterial colonization. Many bacterial proteins are delivered to the host cell for subverting the inflammatory response. Hereby, we have highlighted the specific processes used by E. Coli pathotypes, by that subvert the inflammatory pathways. These mechanisms include an arrangement of pro- and anti-inflammatory responses to favor the appropriate environmental niche for the bacterial survival and growth.

Original languageEnglish (US)
Pages (from-to)1009-1033
Number of pages25
JournalFuture Microbiology
Volume10
Issue number6
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Keywords

  • bacterial effector
  • diarrheagenic E. Coli
  • epithelial cells
  • intestinal inflammation
  • pathogenesis
  • proinflammatory cytokines
  • signaling pathway
  • toxins

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Medicine(all)

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