Role of Wnt signaling during inflammation and sepsis

A review of the literature

Khosrow Siamak Houschyar, Malcolm P. Chelliah, Susanne Rein, Zeshaan N. Maan, Kristian Weissenberg, Dominik Duscher, Ludwik Branski, Frank Siemers

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Despite the development of modern intensive care and new antimicrobial agents, the mortality of patients with severe sepsis and septic shock remains high. Systemic inflammation is a consequence of activation of the innate immune system. It is characterized by the intravascular release of proinflammatory cytokines and other vasoactive mediators, with concurrent activation of innate immune cells. The Wnt signaling pathway plays a critical role in the development of multicellular organisms. Abnormal Wnt signaling has been associated with many human diseases, ranging from inflammation and degenerative diseases to cancer. This article reviews the accumulating evidence that the Wnt signaling pathway plays a distinct role in inflammation and sepsis.

Original languageEnglish (US)
JournalInternational Journal of Artificial Organs
DOIs
StateAccepted/In press - Mar 1 2018

Fingerprint

Sepsis
Wnt Signaling Pathway
Inflammation
Chemical activation
Antimicrobial agents
Immune system
Critical Care
Septic Shock
Anti-Infective Agents
Immune System
Cytokines
Mortality
Neoplasms

Keywords

  • inflammation
  • sepsis
  • Wnt signaling

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Houschyar, K. S., Chelliah, M. P., Rein, S., Maan, Z. N., Weissenberg, K., Duscher, D., ... Siemers, F. (Accepted/In press). Role of Wnt signaling during inflammation and sepsis: A review of the literature. International Journal of Artificial Organs. https://doi.org/10.1177/0391398818762357

Role of Wnt signaling during inflammation and sepsis : A review of the literature. / Houschyar, Khosrow Siamak; Chelliah, Malcolm P.; Rein, Susanne; Maan, Zeshaan N.; Weissenberg, Kristian; Duscher, Dominik; Branski, Ludwik; Siemers, Frank.

In: International Journal of Artificial Organs, 01.03.2018.

Research output: Contribution to journalArticle

Houschyar, Khosrow Siamak ; Chelliah, Malcolm P. ; Rein, Susanne ; Maan, Zeshaan N. ; Weissenberg, Kristian ; Duscher, Dominik ; Branski, Ludwik ; Siemers, Frank. / Role of Wnt signaling during inflammation and sepsis : A review of the literature. In: International Journal of Artificial Organs. 2018.
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