Role of Wnt signaling during inflammation and sepsis: A review of the literature

Khosrow Siamak Houschyar, Malcolm P. Chelliah, Susanne Rein, Zeshaan N. Maan, Kristian Weissenberg, Dominik Duscher, Ludwik K. Branski, Frank Siemers

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Despite the development of modern intensive care and new antimicrobial agents, the mortality of patients with severe sepsis and septic shock remains high. Systemic inflammation is a consequence of activation of the innate immune system. It is characterized by the intravascular release of proinflammatory cytokines and other vasoactive mediators, with concurrent activation of innate immune cells. The Wnt signaling pathway plays a critical role in the development of multicellular organisms. Abnormal Wnt signaling has been associated with many human diseases, ranging from inflammation and degenerative diseases to cancer. This article reviews the accumulating evidence that the Wnt signaling pathway plays a distinct role in inflammation and sepsis.

Original languageEnglish (US)
JournalInternational Journal of Artificial Organs
DOIs
StateAccepted/In press - Mar 1 2018

Keywords

  • Wnt signaling
  • inflammation
  • sepsis

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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