Abstract
Advance therapies which effectively reduce mortality in lung cancer patients become a global health challenge nowadays. Sufficient knowledge regarding cellular and molecular basis of cancer progression and metastasis would possibly help in the development of novel and effective strategies for the treatment of this disease. This review focuses on the information regarding the role and mechanism of caveolin-1 (Cav-1) protein on anoikis in Non Small Cell Lung Cancer (NSCLC). NSCLC accounts of approximately 80% of all diagnosed lung cancer cases which patients frequently presented with metastatic disease. Like other cancers, caveolin-1 (Cav-1) has been shown to play an important role in regulating cancer-cells behaviors including apoptosis resistance and metastasis. Even though further investigations as well as in vivo experiments are required, these data are of great interest and may be beneficial to the development of lung cancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 149-155 |
| Number of pages | 7 |
| Journal | International Journal of Physiology, Pathophysiology and Pharmacology |
| Volume | 4 |
| Issue number | 3 |
| State | Published - 2012 |
| Externally published | Yes |
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Keywords
- Anoikis resistance
- Apoptosis resistance
- Cancer therapy
- Caveolin-1 (Cav-1)
- Metastasis
- Non small cell lung cancer (NSCLC)
ASJC Scopus subject areas
- Physiology (medical)
- Physiology
- Pathology and Forensic Medicine
Cite this
Roles of caveolin-1 on anoikis resistance in non small cell lung cancer. / Chunhacha, Preedakorn; Chanvorachote, Pithi.
In: International Journal of Physiology, Pathophysiology and Pharmacology, Vol. 4, No. 3, 2012, p. 149-155.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Roles of caveolin-1 on anoikis resistance in non small cell lung cancer
AU - Chunhacha, Preedakorn
AU - Chanvorachote, Pithi
PY - 2012
Y1 - 2012
N2 - Advance therapies which effectively reduce mortality in lung cancer patients become a global health challenge nowadays. Sufficient knowledge regarding cellular and molecular basis of cancer progression and metastasis would possibly help in the development of novel and effective strategies for the treatment of this disease. This review focuses on the information regarding the role and mechanism of caveolin-1 (Cav-1) protein on anoikis in Non Small Cell Lung Cancer (NSCLC). NSCLC accounts of approximately 80% of all diagnosed lung cancer cases which patients frequently presented with metastatic disease. Like other cancers, caveolin-1 (Cav-1) has been shown to play an important role in regulating cancer-cells behaviors including apoptosis resistance and metastasis. Even though further investigations as well as in vivo experiments are required, these data are of great interest and may be beneficial to the development of lung cancer therapy.
AB - Advance therapies which effectively reduce mortality in lung cancer patients become a global health challenge nowadays. Sufficient knowledge regarding cellular and molecular basis of cancer progression and metastasis would possibly help in the development of novel and effective strategies for the treatment of this disease. This review focuses on the information regarding the role and mechanism of caveolin-1 (Cav-1) protein on anoikis in Non Small Cell Lung Cancer (NSCLC). NSCLC accounts of approximately 80% of all diagnosed lung cancer cases which patients frequently presented with metastatic disease. Like other cancers, caveolin-1 (Cav-1) has been shown to play an important role in regulating cancer-cells behaviors including apoptosis resistance and metastasis. Even though further investigations as well as in vivo experiments are required, these data are of great interest and may be beneficial to the development of lung cancer therapy.
KW - Anoikis resistance
KW - Apoptosis resistance
KW - Cancer therapy
KW - Caveolin-1 (Cav-1)
KW - Metastasis
KW - Non small cell lung cancer (NSCLC)
UR - http://www.scopus.com/inward/record.url?scp=84867062532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867062532&partnerID=8YFLogxK
M3 - Article
VL - 4
SP - 149
EP - 155
JO - International Journal of Physiology, Pathophysiology and Pharmacology
JF - International Journal of Physiology, Pathophysiology and Pharmacology
SN - 1944-8171
IS - 3
ER -