Roles of gastrointestinal hormones in pancreatic cancer

Yan Shi Guo, Courtney Townsend

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Several gastrointestinal (GI) hormones, such as gastrin, cholecystokinin, and bombesin, have been reported to affect the development of pancreatic cancer. The receptors for these hormones are found in normal and neoplastic pancreatic cells. Activation of these receptors enhances pancreatic carcinogenesis and promotes the growth of established pancreatic carcinoma either in vitro or in vivo. On the other hand, some studies have shown that these GI hormones may have no effect or may play an inhibitory role in the development of pancreatic cancer. The reasons for the apparent discrepancies in the published literature are discussed in this review. In recent years, increasing emphasis has been placed on the effects of GI hormones on cancer invasion and metastasis. As the transition from noninvasion to the invasive state is the crucial event in cancer development, further investigation of the way in which GI hormones affect the invasion and metastasis of pancreatic cancer may be important for the development of new therapeutic approaches with eventual clinical utility.

Original languageEnglish (US)
Pages (from-to)276-285
Number of pages10
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume7
Issue number3
StatePublished - 2000

Fingerprint

Gastrointestinal Hormones
Pancreatic Neoplasms
Neoplasm Metastasis
Bombesin
Cholecystokinin
Gastrins
Neoplasms
Carcinogenesis
Hormones
Growth

Keywords

  • Bombesin
  • Cholecystokinin
  • Gastrin
  • Metastasis
  • Pancreatic cancer

ASJC Scopus subject areas

  • Surgery

Cite this

Roles of gastrointestinal hormones in pancreatic cancer. / Guo, Yan Shi; Townsend, Courtney.

In: Journal of Hepato-Biliary-Pancreatic Surgery, Vol. 7, No. 3, 2000, p. 276-285.

Research output: Contribution to journalArticle

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