Roles of mitochondria in neutrophils

Ziming Cao, Meng Zhao, Hao Sun, Liang Hu, Yunfeng Chen, Zhichao Fan

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Neutrophils are the most abundant leukocyte in human blood. They are critical for fighting infections and are involved in inflammatory diseases. Mitochondria are indispensable for eukaryotic cells, as they control the biochemical processes of respiration and energy production. Mitochondria in neutrophils have been underestimated since glycolysis is a major metabolic pathway for fuel production in neutrophils. However, several studies have shown that mitochondria are greatly involved in multiple neutrophil functions as well as neutrophil-related diseases. In this review, we focus on how mitochondrial components, metabolism, and related genes regulate neutrophil functions and relevant diseases.

Original languageEnglish (US)
Article number934444
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Aug 19 2022
Externally publishedYes

Keywords

  • NETosis
  • adhesion
  • migration
  • mitochondria
  • neutrophils
  • respiratory burst

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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