Roles of NHERF Family of PDZ-Binding Proteins in Regulating GPCR Functions

David Broadbent, Mohammad M. Ahmadzai, Ananth K. Kammala, Canchai Yang, Christopher Occhiuto, Rupali Das, Hariharan Subramanian

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Multicellular organisms are equipped with an array of G-protein-coupled receptors (GPCRs) that mediate cell–cell signaling allowing them to adapt to environmental cues and ultimately survive. This is mechanistically possible through complex intracellular GPCR machinery that encompasses a vast network of proteins. Within this network, there is a group called scaffolding proteins that facilitate proper localization of signaling proteins for a quick and robust GPCR response. One protein family within this scaffolding group is the PSD-95/Dlg/ZO-1 (PDZ) family which is important for GPCR localization, internalization, recycling, and downstream signaling. Although the PDZ family of proteins regulate the functions of several receptors, this chapter focuses on a subfamily within the PDZ protein family called the Na+/H+ exchanger regulatory factors (NHERFs). Here we extensively review the predominantly characterized roles of NHERFs in renal phosphate absorption, intestinal ion regulation, cancer progression, and immune cell functions. Finally, we discuss the future perspectives and possible clinical application of targeting NHERFs in several disorders.

Original languageEnglish (US)
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Pages353-385
Number of pages33
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameAdvances in Immunology
Volume136
ISSN (Print)0065-2776
ISSN (Electronic)1557-8445

Keywords

  • CFTR
  • EBP50
  • G-protein-coupled receptors
  • Na/H exchanger regulatory factor 1
  • NHERFs
  • PDZ proteins
  • PDZK1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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