Roles of the coding and noncoding regions of rift valley fever virus RNA genome segments in viral RNA packaging

Shin Murakami, Kaori Terasaki, Krishna Narayanan, Shinji Makino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We characterized the RNA elements involved in the packaging of Rift Valley fever virus RNA genome segments, L, M, and S. The 5′-terminal 25 nucleotides of each RNA segment were equally competent for RNA packaging and carried an RNA packaging signal, which overlapped with the RNA replication signal. Only the deletion mutants of L RNA, but not full-length L RNA, were efficiently packaged, implying the possible requirement of RNA compaction for L RNA packaging.

Original languageEnglish (US)
Pages (from-to)4034-4039
Number of pages6
JournalJournal of Virology
Volume86
Issue number7
DOIs
StatePublished - Apr 2012

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Rift Valley fever virus
Virus Assembly
Viral RNA
Genome
RNA
genome
Product Packaging
packaging
RNA packaging
nucleotides
mutants
Nucleotides

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Roles of the coding and noncoding regions of rift valley fever virus RNA genome segments in viral RNA packaging. / Murakami, Shin; Terasaki, Kaori; Narayanan, Krishna; Makino, Shinji.

In: Journal of Virology, Vol. 86, No. 7, 04.2012, p. 4034-4039.

Research output: Contribution to journalArticle

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