Roles of the coding and noncoding regions of rift valley fever virus RNA genome segments in viral RNA packaging

Shin Murakami, Kaori Terasaki, Krishna Narayanan, Shinji Makino

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We characterized the RNA elements involved in the packaging of Rift Valley fever virus RNA genome segments, L, M, and S. The 5′-terminal 25 nucleotides of each RNA segment were equally competent for RNA packaging and carried an RNA packaging signal, which overlapped with the RNA replication signal. Only the deletion mutants of L RNA, but not full-length L RNA, were efficiently packaged, implying the possible requirement of RNA compaction for L RNA packaging.

Original languageEnglish (US)
Pages (from-to)4034-4039
Number of pages6
JournalJournal of virology
Volume86
Issue number7
DOIs
StatePublished - Apr 1 2012

    Fingerprint

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this