Ross River virus (Togaviridae: Alphavirus) infection (epidemic polyarthritis) in American Samoa

Robert B. Tesh, Robert G. McLean, Donald A. Shroyer, Charles H. Calisher, Leon Rosen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

An outbreak of Ross River virus infection (epidemic polyarthritis), which occurred in American Samoa between August 1979 and January 1980, is described. On the basis of a serological survey performed near the end of the epidemic, it is estimated that at least 13,500 people were infected. Ross River virus was isolated from the blood of a single polyarthritis patient. Plaque reduction neutralization tests, using this virus strain, were done on 393 human and 143 animal sera collected on Tutuila island. Over-all, 43·8% of the people sampled had evidence of infection. Sera from 100 adult residents of the same island, collected in 1972, had no Ross River antibody, suggesting recent introduction of the virus. In contrast to the human serological data, the prevalence of Ross River antibodies among animals was relatively low. Dogs and pigs had the highest rates with 20% and 15%, respectively. Results of this study suggest that the Ross River virus cycle during the epidemic in American Samoa involved primarily humans and mosquitoes with animals less frequently infected. These observations plus the recent introduction of Ross River virus into new areas of the South Pacific suggest that a major change has occurred in the epidemiology of epidemic polyarthritis.

Original languageEnglish (US)
Pages (from-to)426-431
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume75
Issue number3
DOIs
StatePublished - 1981
Externally publishedYes

Fingerprint

Togaviridae Infections
Alphavirus Infections
American Samoa
Ross River virus
Arthritis
Islands
Rivers
Viruses
Neutralization Tests
Antibodies
Virus Diseases
Culicidae
Serum
Disease Outbreaks
Epidemiology
Swine
Dogs
Infection

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

Cite this

Ross River virus (Togaviridae : Alphavirus) infection (epidemic polyarthritis) in American Samoa. / Tesh, Robert B.; McLean, Robert G.; Shroyer, Donald A.; Calisher, Charles H.; Rosen, Leon.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 75, No. 3, 1981, p. 426-431.

Research output: Contribution to journalArticle

Tesh, Robert B. ; McLean, Robert G. ; Shroyer, Donald A. ; Calisher, Charles H. ; Rosen, Leon. / Ross River virus (Togaviridae : Alphavirus) infection (epidemic polyarthritis) in American Samoa. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 1981 ; Vol. 75, No. 3. pp. 426-431.
@article{05063da16312452db390746961ed56e8,
title = "Ross River virus (Togaviridae: Alphavirus) infection (epidemic polyarthritis) in American Samoa",
abstract = "An outbreak of Ross River virus infection (epidemic polyarthritis), which occurred in American Samoa between August 1979 and January 1980, is described. On the basis of a serological survey performed near the end of the epidemic, it is estimated that at least 13,500 people were infected. Ross River virus was isolated from the blood of a single polyarthritis patient. Plaque reduction neutralization tests, using this virus strain, were done on 393 human and 143 animal sera collected on Tutuila island. Over-all, 43·8{\%} of the people sampled had evidence of infection. Sera from 100 adult residents of the same island, collected in 1972, had no Ross River antibody, suggesting recent introduction of the virus. In contrast to the human serological data, the prevalence of Ross River antibodies among animals was relatively low. Dogs and pigs had the highest rates with 20{\%} and 15{\%}, respectively. Results of this study suggest that the Ross River virus cycle during the epidemic in American Samoa involved primarily humans and mosquitoes with animals less frequently infected. These observations plus the recent introduction of Ross River virus into new areas of the South Pacific suggest that a major change has occurred in the epidemiology of epidemic polyarthritis.",
author = "Tesh, {Robert B.} and McLean, {Robert G.} and Shroyer, {Donald A.} and Calisher, {Charles H.} and Leon Rosen",
year = "1981",
doi = "10.1016/0035-9203(81)90112-7",
language = "English (US)",
volume = "75",
pages = "426--431",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Ross River virus (Togaviridae

T2 - Alphavirus) infection (epidemic polyarthritis) in American Samoa

AU - Tesh, Robert B.

AU - McLean, Robert G.

AU - Shroyer, Donald A.

AU - Calisher, Charles H.

AU - Rosen, Leon

PY - 1981

Y1 - 1981

N2 - An outbreak of Ross River virus infection (epidemic polyarthritis), which occurred in American Samoa between August 1979 and January 1980, is described. On the basis of a serological survey performed near the end of the epidemic, it is estimated that at least 13,500 people were infected. Ross River virus was isolated from the blood of a single polyarthritis patient. Plaque reduction neutralization tests, using this virus strain, were done on 393 human and 143 animal sera collected on Tutuila island. Over-all, 43·8% of the people sampled had evidence of infection. Sera from 100 adult residents of the same island, collected in 1972, had no Ross River antibody, suggesting recent introduction of the virus. In contrast to the human serological data, the prevalence of Ross River antibodies among animals was relatively low. Dogs and pigs had the highest rates with 20% and 15%, respectively. Results of this study suggest that the Ross River virus cycle during the epidemic in American Samoa involved primarily humans and mosquitoes with animals less frequently infected. These observations plus the recent introduction of Ross River virus into new areas of the South Pacific suggest that a major change has occurred in the epidemiology of epidemic polyarthritis.

AB - An outbreak of Ross River virus infection (epidemic polyarthritis), which occurred in American Samoa between August 1979 and January 1980, is described. On the basis of a serological survey performed near the end of the epidemic, it is estimated that at least 13,500 people were infected. Ross River virus was isolated from the blood of a single polyarthritis patient. Plaque reduction neutralization tests, using this virus strain, were done on 393 human and 143 animal sera collected on Tutuila island. Over-all, 43·8% of the people sampled had evidence of infection. Sera from 100 adult residents of the same island, collected in 1972, had no Ross River antibody, suggesting recent introduction of the virus. In contrast to the human serological data, the prevalence of Ross River antibodies among animals was relatively low. Dogs and pigs had the highest rates with 20% and 15%, respectively. Results of this study suggest that the Ross River virus cycle during the epidemic in American Samoa involved primarily humans and mosquitoes with animals less frequently infected. These observations plus the recent introduction of Ross River virus into new areas of the South Pacific suggest that a major change has occurred in the epidemiology of epidemic polyarthritis.

UR - http://www.scopus.com/inward/record.url?scp=0019763703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019763703&partnerID=8YFLogxK

U2 - 10.1016/0035-9203(81)90112-7

DO - 10.1016/0035-9203(81)90112-7

M3 - Article

C2 - 7324110

AN - SCOPUS:0019763703

VL - 75

SP - 426

EP - 431

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 3

ER -