Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication

Junhong Han, Hui Zhou, Bruce Horazdovsky, Kangling Zhang, Rui Ming Xu, Zhiguo Zhang

Research output: Contribution to journalArticlepeer-review

349 Scopus citations


Acetylation of histone H3 lysine 56 (H3-K56) occurs in S phase, and cells lacking H3-K56 acetylation are sensitive to DNA-damaging agents. However, the histone acetyltransferase (HAT) that catalyzes global H3-K56 acetylation has not been found. Here we show that regulation of Ty1 transposition gene product 109 (Rtt109) is an H3-K56 HAT. Cells lacking Rtt109 or expressing rtt109 mutants with alterations at a conserved aspartate residue lose H3-K56 acetylation and exhibit increased sensitivity toward genotoxic agents, as well as elevated levels of spontaneous chromosome breaks. Thus, Rtt109, which shares no sequence homology with any other known HATs, is a unique HAT that acetylates H3-K56.

Original languageEnglish (US)
Pages (from-to)653-655
Number of pages3
Issue number5812
StatePublished - Feb 2 2007
Externally publishedYes

ASJC Scopus subject areas

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