"Russell body gastroenterocolitis" in a posttransplant patient

Palawinnage Muthukumarana, Sheila Segura, Miechelle O'Brien, R. I.N.A. Siddiqui, Hani El-Fanek

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Russell bodies represent a cellular response to overstimulation of plasma cells, leading to the accumulation of abundant, nondegradable, condensed immunoglobulin in dilated rough endoplasmic reticulum cisternae. Russell body gastritis was first described 1998 by Tazawa and Tsutsumi. Since then only 39 cases involving the gastrointestinal tract have been reported in English literature, which include Russell body gastritis, duodenitis, and esophagitis. We report a case of a 44-year-old female with a history of diabetes mellitus, status post kidney and pancreas transplant who presented with multiple episodes of watery diarrhea associated with abdominal pain, nausea, and vomiting. Upper gastroendoscopic examination showed diffuse mild erythema in the gastric body and a clean-based duodenal ulcer. Lower gastroendoscopic examination was normal. Examination of multiple biopsies from duodenal, gastric, terminal ileum, and colonic mucosae revealed numerous plasma cells with abundant eosinophilic granular cytoplasm (Russell bodies) and eccentric nuclei, highlighted by PAS stain and CD 138 plasma cell marker. Helicobacter pylori stains were performed on gastric biopsies and were negative for organisms. To date, there are no cases described in English literature with multifocal Russell body infiltrates in gastrointestinal tract in a single patient including ileum and/or colon. This makes our case the first to be reported with these unique findings; thus, the spectrum of Russell body-associated chronic inflammation of the gastrointestinal tract would be more suitably referred to as "Russell body gastroenterocolitis."

Original languageEnglish (US)
Pages (from-to)667-672
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume23
Issue number8
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

Fingerprint

Plasma Cells
Literature
Gastrointestinal Tract
Stomach
Gastritis
Ileum
Coloring Agents
Duodenitis
Biopsy
Esophagitis
Rough Endoplasmic Reticulum
Erythema
Duodenal Ulcer
Helicobacter pylori
Nausea
Abdominal Pain
Vomiting
Immunoglobulins
Pancreas
Diarrhea

Keywords

  • gastritis
  • gastroenterocolitis
  • Russell body

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

"Russell body gastroenterocolitis" in a posttransplant patient. / Muthukumarana, Palawinnage; Segura, Sheila; O'Brien, Miechelle; Siddiqui, R. I.N.A.; El-Fanek, Hani.

In: International Journal of Surgical Pathology, Vol. 23, No. 8, 01.12.2015, p. 667-672.

Research output: Contribution to journalArticle

Muthukumarana, Palawinnage ; Segura, Sheila ; O'Brien, Miechelle ; Siddiqui, R. I.N.A. ; El-Fanek, Hani. / "Russell body gastroenterocolitis" in a posttransplant patient. In: International Journal of Surgical Pathology. 2015 ; Vol. 23, No. 8. pp. 667-672.
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