Sacral neuromodulation for overactive bladder in women: do age and comorbidities make a difference?

Rachel A. High, William Winkelman, Joseph Panza, Derrick J. Sanderson, Hyde Yuen, Gabriela Halder, Courtney Shaver, Erin T. Bird, Rebecca G. Rogers, Jill M. Danford

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective: To evaluate if age and comorbidities are associated with progression from trial phase to implantation of an implantable pulse generator in women with overactive bladder. Methods: This multisite retrospective cohort included women with overactive bladder with or without urinary incontinence who had a trial phase for sacral neuromodulation. The primary outcome was progression to implantation. A sub-analysis of implanted patients was performed for the outcome of additional therapies or “implant only” for the duration of follow-up. Multivariate logistic regression models including potential predictors of implantation and post-implantation addition of therapies were performed. Results: At six academic institutions, 91% (785/864) of patients progressed to implantation. Post-implantation success was achieved by 69% (536/782) of patients at median follow-up of 2 (range 0.3 to 15) years. Odds of implantation [OR 0.73 (CI 0.61, 0.88)] and post-implantation success [OR 0.78 (CI 0.98, 0.97)] were lower with increasing decades of age. Medical comorbidities evaluated did not affect implantation rates or post-implant success. Conclusions: Most women have successful sacral neuromodulation trials despite older age and comorbidities. Higher decade of age has a negative effect on odds of implantation and is associated with addition of therapies post-implantation. Comorbidities assessed in this study did not affect implantation or addition of therapies post-implantation. Most women add therapies to improve efficacy post-implantation, and explantation rates are low.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalInternational Urogynecology Journal
Issue number1
StatePublished - Jan 2021
Externally publishedYes


  • Aging
  • Elderly
  • Overactive bladder
  • Sacral neuromodulation
  • Urinary incontinence

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Urology


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