Abstract
To determine the safety of glutamine-enriched parenteral nutrition, seven normal volunteers were admitted to the Clinical Research Center for three 5-d study periods. The subjects received infusions of parenteral nutrients containing increasing doses of glutamine (0, 0.285, and 0.570 g·kg body wt-1·d-1) substituted for alanine and glycine. Each study period was preceded by ≥ 2 wk of normal food intake. The diets were isocaloric (1.2× estimated basal metabolic rate) and isonitrogenous (1.5 g protein·kg-1·d-1) with nonprotein calories given as dextrose (38%) and fat emulsion (62%). The diets were all well tolerated and there were no untoward effects. Plasma glutamine concentrations increased significantly with glutamine administration but plateaued at concentrations ∼ 25% above control values. Ammonia and glutamate, potentially toxic metabolites of glutamine, did not change significantly with glutamine enrichment. Nitrogen balance and hormonal concentrations were unchanged during the three dietary periods. Results of mental-status examinations and continuous performance testing were normal and unchanged throughout the three periods. Glutamine-enriched parenteral nutrient solutions are well tolerated with no associated signs of toxicity in normal humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1101-1106 |
| Number of pages | 6 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 52 |
| Issue number | 6 |
| State | Published - Dec 1990 |
| Externally published | Yes |
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Keywords
- Glutamate
- Glutamine
- Intravenous nutrition
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Safety of glutamine-enriched parenteral nutrient solutions in humans. / Lowe, Daniel K.; Benfell, Kathleen; Smith, Robert J.; Jacobs, Danny O.; Murawski, Benjamin; Ziegler, Thomas R.; Wilmore, Douglas W.
In: American Journal of Clinical Nutrition, Vol. 52, No. 6, 12.1990, p. 1101-1106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Safety of glutamine-enriched parenteral nutrient solutions in humans
AU - Lowe, Daniel K.
AU - Benfell, Kathleen
AU - Smith, Robert J.
AU - Jacobs, Danny O.
AU - Murawski, Benjamin
AU - Ziegler, Thomas R.
AU - Wilmore, Douglas W.
PY - 1990/12
Y1 - 1990/12
N2 - To determine the safety of glutamine-enriched parenteral nutrition, seven normal volunteers were admitted to the Clinical Research Center for three 5-d study periods. The subjects received infusions of parenteral nutrients containing increasing doses of glutamine (0, 0.285, and 0.570 g·kg body wt-1·d-1) substituted for alanine and glycine. Each study period was preceded by ≥ 2 wk of normal food intake. The diets were isocaloric (1.2× estimated basal metabolic rate) and isonitrogenous (1.5 g protein·kg-1·d-1) with nonprotein calories given as dextrose (38%) and fat emulsion (62%). The diets were all well tolerated and there were no untoward effects. Plasma glutamine concentrations increased significantly with glutamine administration but plateaued at concentrations ∼ 25% above control values. Ammonia and glutamate, potentially toxic metabolites of glutamine, did not change significantly with glutamine enrichment. Nitrogen balance and hormonal concentrations were unchanged during the three dietary periods. Results of mental-status examinations and continuous performance testing were normal and unchanged throughout the three periods. Glutamine-enriched parenteral nutrient solutions are well tolerated with no associated signs of toxicity in normal humans.
AB - To determine the safety of glutamine-enriched parenteral nutrition, seven normal volunteers were admitted to the Clinical Research Center for three 5-d study periods. The subjects received infusions of parenteral nutrients containing increasing doses of glutamine (0, 0.285, and 0.570 g·kg body wt-1·d-1) substituted for alanine and glycine. Each study period was preceded by ≥ 2 wk of normal food intake. The diets were isocaloric (1.2× estimated basal metabolic rate) and isonitrogenous (1.5 g protein·kg-1·d-1) with nonprotein calories given as dextrose (38%) and fat emulsion (62%). The diets were all well tolerated and there were no untoward effects. Plasma glutamine concentrations increased significantly with glutamine administration but plateaued at concentrations ∼ 25% above control values. Ammonia and glutamate, potentially toxic metabolites of glutamine, did not change significantly with glutamine enrichment. Nitrogen balance and hormonal concentrations were unchanged during the three dietary periods. Results of mental-status examinations and continuous performance testing were normal and unchanged throughout the three periods. Glutamine-enriched parenteral nutrient solutions are well tolerated with no associated signs of toxicity in normal humans.
KW - Glutamate
KW - Glutamine
KW - Intravenous nutrition
UR - http://www.scopus.com/inward/record.url?scp=0025222248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025222248&partnerID=8YFLogxK
M3 - Article
C2 - 2122714
AN - SCOPUS:0025222248
VL - 52
SP - 1101
EP - 1106
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6
ER -