Safety of glutamine-enriched parenteral nutrient solutions in humans

Daniel K. Lowe, Kathleen Benfell, Robert J. Smith, Danny O. Jacobs, Benjamin Murawski, Thomas R. Ziegler, Douglas W. Wilmore

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

To determine the safety of glutamine-enriched parenteral nutrition, seven normal volunteers were admitted to the Clinical Research Center for three 5-d study periods. The subjects received infusions of parenteral nutrients containing increasing doses of glutamine (0, 0.285, and 0.570 g·kg body wt-1·d-1) substituted for alanine and glycine. Each study period was preceded by ≥ 2 wk of normal food intake. The diets were isocaloric (1.2× estimated basal metabolic rate) and isonitrogenous (1.5 g protein·kg-1·d-1) with nonprotein calories given as dextrose (38%) and fat emulsion (62%). The diets were all well tolerated and there were no untoward effects. Plasma glutamine concentrations increased significantly with glutamine administration but plateaued at concentrations ∼ 25% above control values. Ammonia and glutamate, potentially toxic metabolites of glutamine, did not change significantly with glutamine enrichment. Nitrogen balance and hormonal concentrations were unchanged during the three dietary periods. Results of mental-status examinations and continuous performance testing were normal and unchanged throughout the three periods. Glutamine-enriched parenteral nutrient solutions are well tolerated with no associated signs of toxicity in normal humans.

Original languageEnglish (US)
Pages (from-to)1101-1106
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume52
Issue number6
StatePublished - Dec 1990
Externally publishedYes

Fingerprint

Glutamine
glutamine
nutrient solutions
Safety
Parenteral Infusions
Diet
Basal Metabolism
basal metabolic rate
Poisons
Parenteral Nutrition
parenteral feeding
nitrogen balance
Emulsions
Ammonia
glycine (amino acid)
diet
glutamates
Alanine
Glycine
alanine

Keywords

  • Glutamate
  • Glutamine
  • Intravenous nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lowe, D. K., Benfell, K., Smith, R. J., Jacobs, D. O., Murawski, B., Ziegler, T. R., & Wilmore, D. W. (1990). Safety of glutamine-enriched parenteral nutrient solutions in humans. American Journal of Clinical Nutrition, 52(6), 1101-1106.

Safety of glutamine-enriched parenteral nutrient solutions in humans. / Lowe, Daniel K.; Benfell, Kathleen; Smith, Robert J.; Jacobs, Danny O.; Murawski, Benjamin; Ziegler, Thomas R.; Wilmore, Douglas W.

In: American Journal of Clinical Nutrition, Vol. 52, No. 6, 12.1990, p. 1101-1106.

Research output: Contribution to journalArticle

Lowe, DK, Benfell, K, Smith, RJ, Jacobs, DO, Murawski, B, Ziegler, TR & Wilmore, DW 1990, 'Safety of glutamine-enriched parenteral nutrient solutions in humans', American Journal of Clinical Nutrition, vol. 52, no. 6, pp. 1101-1106.
Lowe DK, Benfell K, Smith RJ, Jacobs DO, Murawski B, Ziegler TR et al. Safety of glutamine-enriched parenteral nutrient solutions in humans. American Journal of Clinical Nutrition. 1990 Dec;52(6):1101-1106.
Lowe, Daniel K. ; Benfell, Kathleen ; Smith, Robert J. ; Jacobs, Danny O. ; Murawski, Benjamin ; Ziegler, Thomas R. ; Wilmore, Douglas W. / Safety of glutamine-enriched parenteral nutrient solutions in humans. In: American Journal of Clinical Nutrition. 1990 ; Vol. 52, No. 6. pp. 1101-1106.
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