Safety of recombinant VSV-Ebola virus vaccine vector in pigs

Emmie De Wit, Andrea Marzi, Trenton Bushmaker, Doug Brining, Dana Scott, Juergen A. Richt, Thomas Geisbert, Heinz Feldmann

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.

Original languageEnglish (US)
Pages (from-to)702-704
Number of pages3
JournalEmerging Infectious Diseases
Volume21
Issue number4
DOIs
StatePublished - 2015

Fingerprint

Ebola Vaccines
Swine
Vaccines
Safety
Ebolavirus
Viruses
Virus Shedding
Vesicular Stomatitis
Western Africa
Disease Outbreaks
Glycoproteins

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

De Wit, E., Marzi, A., Bushmaker, T., Brining, D., Scott, D., Richt, J. A., ... Feldmann, H. (2015). Safety of recombinant VSV-Ebola virus vaccine vector in pigs. Emerging Infectious Diseases, 21(4), 702-704. https://doi.org/10.3201/eid2104.142012

Safety of recombinant VSV-Ebola virus vaccine vector in pigs. / De Wit, Emmie; Marzi, Andrea; Bushmaker, Trenton; Brining, Doug; Scott, Dana; Richt, Juergen A.; Geisbert, Thomas; Feldmann, Heinz.

In: Emerging Infectious Diseases, Vol. 21, No. 4, 2015, p. 702-704.

Research output: Contribution to journalArticle

De Wit, E, Marzi, A, Bushmaker, T, Brining, D, Scott, D, Richt, JA, Geisbert, T & Feldmann, H 2015, 'Safety of recombinant VSV-Ebola virus vaccine vector in pigs', Emerging Infectious Diseases, vol. 21, no. 4, pp. 702-704. https://doi.org/10.3201/eid2104.142012
De Wit E, Marzi A, Bushmaker T, Brining D, Scott D, Richt JA et al. Safety of recombinant VSV-Ebola virus vaccine vector in pigs. Emerging Infectious Diseases. 2015;21(4):702-704. https://doi.org/10.3201/eid2104.142012
De Wit, Emmie ; Marzi, Andrea ; Bushmaker, Trenton ; Brining, Doug ; Scott, Dana ; Richt, Juergen A. ; Geisbert, Thomas ; Feldmann, Heinz. / Safety of recombinant VSV-Ebola virus vaccine vector in pigs. In: Emerging Infectious Diseases. 2015 ; Vol. 21, No. 4. pp. 702-704.
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