Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis: an international multicenter study

Marita Salame; Yervant Ichkhanian; Nwal Hadaki; John M. Wo; Sarah A. Stainko; Akira Saito; Robert M. Siwiec; Thomas V. Nowak; Andrew Li; Joo Ha Hwang; Juliana Yang; Joseph Broucek; Tuba Esfandyari; Stephanie Joseph; Michael Ujiki; Ashley E. Williams; Jacob R. Moremen; Zane Gouda; Alexander Schlachterman; Kristina Hugova; Jan Martinek; Calvin X. Geng; Alexander Podboy; Andrew Y. Wang; Michael Lajin; Payton Miller; Lennon Gregor; Hashem Albunni; John M. Dewitt; Mohammad A. Al-Haddad

doi:10.1016/j.gie.2025.02.020

Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis: an international multicenter study

Marita Salame, Yervant Ichkhanian, Nwal Hadaki, John M. Wo, Sarah A. Stainko, Akira Saito, Robert M. Siwiec, Thomas V. Nowak, Andrew Li, Joo Ha Hwang, Juliana Yang, Joseph Broucek, Tuba Esfandyari, Stephanie Joseph, Michael Ujiki, Ashley E. Williams, Jacob R. Moremen, Zane Gouda, Alexander Schlachterman, Kristina HugovaJan Martinek, Calvin X. Geng, Alexander Podboy, Andrew Y. Wang, Michael Lajin, Payton Miller, Lennon Gregor, Hashem Albunni, John M. Dewitt, Mohammad A. Al-Haddad

Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Aims: The postoperative management of gastric peroral endoscopic myotomy (G-POEM) lacks standardization. This study aimed to evaluate adverse events, readmission rates, and feasibility of same-day discharge (SDD) after G-POEM. Methods: A multicenter retrospective review of prospectively collected G-POEM data was conducted. The primary outcome was the 15-day readmission rates in SDD and admitted patients. Secondary outcomes included readmission risk factors, clinical success, and adverse events (AEs). Results: We found a 4.1% 15-day readmission rate in 482 patients (95% CI, 3.2%-5.4%). SDD clinical success rates at 6 to 12 months were 54.1% versus 59.7% for the admitted group. The overall AE rate was 4.1%. SDD patients tended to have shorter procedure times and higher frequencies of double myotomy and endoscopic suturing for closure. Conclusions: G-POEM is safe with low incidence of AEs and 15-day readmission rates. SDD appears safe in uncomplicated cases, suggesting that upper gastrointestinal studies after G-POEM may be unnecessary. ClinicalTrials.gov (NCT04434781).

Original language	English (US)
Journal	Gastrointestinal endoscopy
DOIs	https://doi.org/10.1016/j.gie.2025.02.020
State	Accepted/In press - 2025

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Gastroenterology

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Salame, M., Ichkhanian, Y., Hadaki, N., Wo, J. M., Stainko, S. A., Saito, A., Siwiec, R. M., Nowak, T. V., Li, A., Hwang, J. H., Yang, J., Broucek, J., Esfandyari, T., Joseph, S., Ujiki, M., Williams, A. E., Moremen, J. R., Gouda, Z., Schlachterman, A., ... Al-Haddad, M. A. (Accepted/In press). Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis: an international multicenter study. Gastrointestinal endoscopy. https://doi.org/10.1016/j.gie.2025.02.020

Salame, M, Ichkhanian, Y, Hadaki, N, Wo, JM, Stainko, SA, Saito, A, Siwiec, RM, Nowak, TV, Li, A, Hwang, JH, Yang, J, Broucek, J, Esfandyari, T, Joseph, S, Ujiki, M, Williams, AE, Moremen, JR, Gouda, Z, Schlachterman, A, Hugova, K, Martinek, J, Geng, CX, Podboy, A, Wang, AY, Lajin, M, Miller, P, Gregor, L, Albunni, H, Dewitt, JM & Al-Haddad, MA 2025, 'Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis: an international multicenter study', Gastrointestinal endoscopy. https://doi.org/10.1016/j.gie.2025.02.020

@article{6be47cb39f644817a5f2ff04cc98f61c,

title = "Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis: an international multicenter study",

abstract = "Background and Aims: The postoperative management of gastric peroral endoscopic myotomy (G-POEM) lacks standardization. This study aimed to evaluate adverse events, readmission rates, and feasibility of same-day discharge (SDD) after G-POEM. Methods: A multicenter retrospective review of prospectively collected G-POEM data was conducted. The primary outcome was the 15-day readmission rates in SDD and admitted patients. Secondary outcomes included readmission risk factors, clinical success, and adverse events (AEs). Results: We found a 4.1% 15-day readmission rate in 482 patients (95% CI, 3.2%-5.4%). SDD clinical success rates at 6 to 12 months were 54.1% versus 59.7% for the admitted group. The overall AE rate was 4.1%. SDD patients tended to have shorter procedure times and higher frequencies of double myotomy and endoscopic suturing for closure. Conclusions: G-POEM is safe with low incidence of AEs and 15-day readmission rates. SDD appears safe in uncomplicated cases, suggesting that upper gastrointestinal studies after G-POEM may be unnecessary. ClinicalTrials.gov (NCT04434781).",

author = "Marita Salame and Yervant Ichkhanian and Nwal Hadaki and Wo, {John M.} and Stainko, {Sarah A.} and Akira Saito and Siwiec, {Robert M.} and Nowak, {Thomas V.} and Andrew Li and Hwang, {Joo Ha} and Juliana Yang and Joseph Broucek and Tuba Esfandyari and Stephanie Joseph and Michael Ujiki and Williams, {Ashley E.} and Moremen, {Jacob R.} and Zane Gouda and Alexander Schlachterman and Kristina Hugova and Jan Martinek and Geng, {Calvin X.} and Alexander Podboy and Wang, {Andrew Y.} and Michael Lajin and Payton Miller and Lennon Gregor and Hashem Albunni and Dewitt, {John M.} and Al-Haddad, {Mohammad A.}",

note = "Publisher Copyright: {\textcopyright} 2025 American Society for Gastrointestinal Endoscopy",

year = "2025",

doi = "10.1016/j.gie.2025.02.020",

language = "English (US)",

journal = "Gastrointestinal endoscopy",

issn = "0016-5107",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis

T2 - an international multicenter study

AU - Salame, Marita

AU - Ichkhanian, Yervant

AU - Hadaki, Nwal

AU - Wo, John M.

AU - Stainko, Sarah A.

AU - Saito, Akira

AU - Siwiec, Robert M.

AU - Nowak, Thomas V.

AU - Li, Andrew

AU - Hwang, Joo Ha

AU - Yang, Juliana

AU - Broucek, Joseph

AU - Esfandyari, Tuba

AU - Joseph, Stephanie

AU - Ujiki, Michael

AU - Williams, Ashley E.

AU - Moremen, Jacob R.

AU - Gouda, Zane

AU - Schlachterman, Alexander

AU - Hugova, Kristina

AU - Martinek, Jan

AU - Geng, Calvin X.

AU - Podboy, Alexander

AU - Wang, Andrew Y.

AU - Lajin, Michael

AU - Miller, Payton

AU - Gregor, Lennon

AU - Albunni, Hashem

AU - Dewitt, John M.

AU - Al-Haddad, Mohammad A.

PY - 2025

Y1 - 2025

N2 - Background and Aims: The postoperative management of gastric peroral endoscopic myotomy (G-POEM) lacks standardization. This study aimed to evaluate adverse events, readmission rates, and feasibility of same-day discharge (SDD) after G-POEM. Methods: A multicenter retrospective review of prospectively collected G-POEM data was conducted. The primary outcome was the 15-day readmission rates in SDD and admitted patients. Secondary outcomes included readmission risk factors, clinical success, and adverse events (AEs). Results: We found a 4.1% 15-day readmission rate in 482 patients (95% CI, 3.2%-5.4%). SDD clinical success rates at 6 to 12 months were 54.1% versus 59.7% for the admitted group. The overall AE rate was 4.1%. SDD patients tended to have shorter procedure times and higher frequencies of double myotomy and endoscopic suturing for closure. Conclusions: G-POEM is safe with low incidence of AEs and 15-day readmission rates. SDD appears safe in uncomplicated cases, suggesting that upper gastrointestinal studies after G-POEM may be unnecessary. ClinicalTrials.gov (NCT04434781).

AB - Background and Aims: The postoperative management of gastric peroral endoscopic myotomy (G-POEM) lacks standardization. This study aimed to evaluate adverse events, readmission rates, and feasibility of same-day discharge (SDD) after G-POEM. Methods: A multicenter retrospective review of prospectively collected G-POEM data was conducted. The primary outcome was the 15-day readmission rates in SDD and admitted patients. Secondary outcomes included readmission risk factors, clinical success, and adverse events (AEs). Results: We found a 4.1% 15-day readmission rate in 482 patients (95% CI, 3.2%-5.4%). SDD clinical success rates at 6 to 12 months were 54.1% versus 59.7% for the admitted group. The overall AE rate was 4.1%. SDD patients tended to have shorter procedure times and higher frequencies of double myotomy and endoscopic suturing for closure. Conclusions: G-POEM is safe with low incidence of AEs and 15-day readmission rates. SDD appears safe in uncomplicated cases, suggesting that upper gastrointestinal studies after G-POEM may be unnecessary. ClinicalTrials.gov (NCT04434781).

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U2 - 10.1016/j.gie.2025.02.020

DO - 10.1016/j.gie.2025.02.020

M3 - Article

C2 - 39983999

AN - SCOPUS:105004670777

SN - 0016-5107

JO - Gastrointestinal endoscopy

JF - Gastrointestinal endoscopy

ER -

Safety of same-day discharge after gastric peroral endoscopic myotomy in patients with refractory gastroparesis: an international multicenter study

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