Saliva can mediate HIV-1-specific antibody-dependent cell-mediated cytotoxicity

Jenney S. Kim, Pratip Nag, Alan L. Landay, Mario Alves, Mardge H. Cohn, James W. Bremer, Linda L. Baum

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

HIV is not usually transmitted by saliva from HIV-1-infected individuals. Antiviral substances in saliva responsible for this may include HIV-1-specific antibody-dependent cell-mediated cytotoxicity (ADCC). We evaluated saliva ADCC titers of 62 HIV-1-infected women from the Women's Interagency HIV Study (WIHS) and 55 uninfected individuals. HIV-1-infected women were less likely to have ADCC activity in saliva than in serum or cervical lavage fluid (CVL). 24% of HIV-1-positive women and a similar percentage of uninfected women had HIV-1-specific saliva ADCC activity. A significant amount of saliva ADCC activity in infected women was HIV-gp120-specific. These studies demonstrate that HIV-specific ADCC activity can be present in saliva. This activity may contribute to host defence against initial infection with HIV.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalFEMS Immunology and Medical Microbiology
Volume48
Issue number2
DOIs
StatePublished - Nov 2006
Externally publishedYes

Keywords

  • Antibody-dependent cell-mediated cytotoxicity
  • HIV
  • Immunoglobulin
  • Innate immunity
  • Mucosal immunity
  • Saliva

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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