SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency

Alan P. Kozikowski, Marinella Roberti, Kenneth M. Johnson, John S. Bergmann, Richard G. Ball

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Syntheses of a variety of new analogues of cocaine are reported together with their binding affinities and dopamine uptake inhibition activities. The present work further expands the SAR data base for cocaine.

Original languageEnglish (US)
Pages (from-to)1327-1332
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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